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  • Who we serve
    • アカデミア
    • Pharma / Biotech
      Revvity Impact Report

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    • Clinical Laboratories
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    • Healthcare Professionals
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  • Products
    • 研究・開発
      • ゲノム解析
        • IncRNA in Functional Studies
        • Nucleic Acid Isolation
        • NGSワークフロー
        • Microplate Readers
        • マイクロ流体核酸分析
        • CRISPR Technologies
        • RNA Interference
        • トランスフェクション試薬および補助試薬
        • Oligonucleotide Custom Synthesis
        • cDNAs and ORF Clones
        • Single-Cell Sequencing
        • Labeled Nucleotides
        • qPCR
        • ライブラリー調製キット
        • Magnetic Beads
        • Viral Vector Products
        Revvity Impact Report

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      • タンパク質解析
        • Binding Assays
        • イムノアッセイ
        • マイクロ流体によるタンパク質特性評価
        • Microplate Readers
        • マイクロプレート
        • Recombinant Proteins
        • ウェスタンブロッティング
        • Sample Dissociation
        • M-PVA Magnetic Beads
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      • 細胞分析
        • Cell Isolation
        • Cell Lines & Stem Cells
        • Cell Counting and Image Cytometry
        • セルヘルスと細胞生存率
        • Cellular Imaging & Analysis
        • Immunoassays
        • In Vivo Imaging
        • Microplates
        Revvity Impact Report

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      • 研究ソリューション
        • Immunoassays Solutions
        • pHSense Reagents
        • Biomarker Discovery
        • 細胞・遺伝子治療
        • GMP Workflows
        • バイオロジクス
        • 低分子創薬
        • 疾患研究
        • ターゲットクラス
        • 医薬品開発
        • プレシジョン・メディシン・リサーチ
        • 機能ゲノミクススクリーニングソリューション
        • アッセイ開発ワークフロー
        • Physiological Model Solutions
        • Biobanking Workflows
        • Agrigenomics Workflows
        Revvity Impact Report

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        Impact Report

      Revvity Impact Report

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      Impact Report

    • 臨床・診断
      • リプロダクティブ・ヘルス
        • 出生前検査
        • 新生児スクリーニング
        • Newborn Sequencing Research
        • Pregnancy-Relevant Infections
        • Endocrine Reproductive
        • cell-free DNA解析
        • Neonatal Research
        • Preimplantation Genetic Testing
        • PlGF Testing Research
        • 分子細胞遺伝学
      • 感染症
        • 結核マネジメント
        • EUROIMMUN Solutions
        • IDS Solutions
        • Nucleic Acid Isolation for Pathogen Detection
        • Cytomegalovirus
        • SARS-COV-2 Testing Solutions
        • Bacterial & Viral Nucleic Acid Isolation
        • Metagenomics
      • がん
        • ASR Flow Cytometry Antibodies
        • HPV Testing
        • ctDNA Workflows
        • miRNA-seq Analysis
        • Exosome/cfRNA Analysis
        • Targeted Sequencing
        • Mimix Reference Standards
        • Functional Testing
      • 自己免疫(powered by Euroimmun)
        • EUROIMMUN Solutions
        • IDS Solutions
      • 内分泌学
      • アレルギー
      • 神経変性
        • Alzheimer's Disease
        • Amytrophic Lateral Sclerosis (ALS)
        • Neurogranin
        • BACE1
      • ラピッド検査
    • Reagents
      • BioLegend
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      • Cellular Imaging Reagents
        Revvity Impact Report

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        Impact Report

      • chemagic Nucleic Acid Purification Kits
        Revvity Impact Report

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        Impact Report

      • CRISPR Technologies
        Revvity Impact Report

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        Impact Report

      • GPCR Research Reagents
        Revvity Impact Report

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        Impact Report

      • Immunoassays
        Revvity Impact Report

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        Impact Report

      • In Vivo Imaging Reagents
        Revvity Impact Report

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        Impact Report

      • Liquid Scintillation Cocktails
        Revvity Impact Report

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        Impact Report

      • NGS Library Prep Kits
        Revvity Impact Report

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        Impact Report

      • pHSense Reagents
        Revvity Impact Report

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        Impact Report

      • qPCR
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      • Radiochemicals
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        Impact Report

      • RNA Interference
        Revvity Impact Report

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        Impact Report

      • Primary and Secondary Antibodies
        Revvity Impact Report

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        Impact Report

      Revvity Impact Report

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      Impact Report

    • プラットフォームと自動化
      • 核酸分離
        • chemagic Applications
        • chemagic IVD Instruments
        • chemagic IVD Kits
        • chemagic Instruments
        • chemagic Kits
        • M-PVA Magnetic Beads
      • 自動液体分注
        • Flow Cytometry Cocktail Prep Automation
        • リキッドハンドリングワークステーション
        • 自動液体分注アプリケーション
        • 液体分注機消耗品&アクセサリー
      • 統合ラボオートメーション
        • 自動プレートローディング
        • ワークステーションモジュール
        • スケジューリング&コントロールソフトウェア
        • ロボット工学
      • マイクロ流体分析
        • Microfluidic Protein Characterization
        • Microfluidic Nucleic Acid Analysis
      • 検出システムソリューション
        • Plate Reader Accessories
        • マイクロプレートリーダー
        • 放射性物質の検出
        • 放射性化学物質
        • 液体シンチレーションカクテル
        • 放射線測定用消耗品・アクセサリー
      • イメージング
        • Cellular Imaging & Analysis
        • In vivo イメージング
      • Cell Counting and Image Cytometry
      • サンプルのホモジナイゼーション
        • ホモジナイザー
        • ホモジナイザーアクセサリー
        • ホモジナイザー消耗品
        • サンプルの遠心分離
        • サンプルの超音波処理
      • IVDプラットフォーム&オートメーション
        • IVD Nucleic Acid Isolation
        • IVD Automated Liquid Handling
        • IVD Radiometric Detectors
        • EUROIMMUN Instruments
        • IDS Instruments
        • Clinical Applications
      • 消耗品&アクセサリー
        • Cassettes
        • Cell Harvesters
        • In Vivo Imaging Accessories
        • ハイコンテントイメージングアクセサリー
        • Microplates
        • Radioactive Spill Cleaners
        • Scintillation Cocktails
        • Transfer Membranes
        • Charcoal Traps
        • Homogenizer Accessories
        • Homogenizer Consumables
      • Instrument Service & Maintenance
        • On Demand Equipment Service
        • Equipment Service Plans
    • Consumables & Accessories
      Revvity Impact Report

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    • Signals ソフトウエア
      • All Products
        • Signals One
        • ChemDraw
        • Spotfire®
        • Signals Clinical
        • Signals Notebook
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      • All Solutions
        • Biology
        • Discovery Chemistry
        • Clinical & Translational
        • Specialty Chemicals
        • Food/Flavor/Fragrance
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      Revvity Impact Report

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    • Revvity Omics Services
      Revvity Impact Report

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      Impact Report

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  • Services
    • Preclinicalサービス
      • Antibody Drug Conjugate Services
      • Complex Cell Model Screening Services
      • Base Editing Platform
        • Pin-point base editing platform cell line engineering services
        • Pin-point base editing platform pooled tiled screening services
      • Immune Cell Screening
      • Functional Genomic Screening Services
      • Cell Panel Screening
      • Cell Line Engineering
        • CHOSOURCE CLE Services
      • Viral Vector Engineering and Manufacture
    • Revvity Omics Services
      • Revvity Omics Clinical Services
        • Cytogenomics
        • Global Laboratory Network
        • Metabolic Testing
        • Newborn Screening Services
        • Prenatal Screening Services
        • Proactive Testing
        • Rare Disease Testing
        • Specialized and Customized Assays
        • Sponsored Testing Programs
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Revvity Omics Pharma Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • 臨床サービス
      • Revvity Omics Clinical Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Revvity Omics Pharma Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Cellular and Humoral Immunoassays
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Tuberculosis Testing Services
        • Oxford Diagnostic Laboratories Service Closures
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • Customization Services
      • Assays and Reagents
        • Assay Development
        • Compound profiling
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Microplate Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Custom Conjugation & Labeling
        • Custom Labeling
        • Small Molecule
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Radiosynthesis and Labeling
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • ライセンシング
      • Gene Delivery Licensing
      • Gene Expression Systems
        • CHOSOURCE Platform
      • Pin-point™ Base Editing Platform
      • Virus Screening
    • Viral Vector Engineering and Manufacture
      • AAV Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Lentivirus Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • Instrument Service & Maintenance
      • AV Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • Equipment Service Plans
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      • On-demand Equipment Service
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • Customer Training
      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • OEM ソリューション
      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    T-SPOT.TB testing services.

    Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

    Learn more

  • 会社
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  • Brands
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  • ホーム
  • Services
  • Preclinicalサービス
    • Preclinicalサービス
    • Revvity Omics Services
    • 臨床サービス
    • Customization Services
    • ライセンシング
    • Viral Vector Engineering and Manufacture
    • Instrument Service & Maintenance
    • Customer Training
    • OEM ソリューション
  • Cell Line Engineering
    • Antibody Drug Conjugate Services
    • Complex Cell Model Screening Services
    • Base Editing Platform
    • Immune Cell Screening
    • Functional Genomic Screening Services
    • Cell Panel Screening
    • Cell Line Engineering
    • Viral Vector Engineering and Manufacture
cell line engineering

Cell Engineering Services

Your edit. Our expertise.

Working with you, we can support your research with our stellar custom cell line development and cell engineering services, providing support for complex projects where your in-house team may lack the expertise, time or resources.

Our specialized cell line engineering services are backed by an extensive portfolio of gene-editing licences and expertise across hundreds of cell lines to achieve the right edited cell line solution. We have broad capabilities, powered by Revvity´s Dharmacon™ reagents, with a specific focus on complex edits and challenging cell types.

Below are just some of the options, however we can partner with you on your complex and challenging projects. Please contact us and we will be happy to discuss your custom project needs.

Our standard deliverables include:

  • Up to 2 clones with sequence verification
  • Parental cell line
  • Functional verification for Cas9 stable and reporter cell line projects
  • Mycoplasma testing
  • Sterility testing
  • Full IP coverage for R&D under Revvity’s CRISPR licenses
  • Summary project report

Services include:

  • Multigene targeting knockouts
  • Large knock-ins
  • iPSC editing
  • Primary T-cell editing
  • Polyploid cancer line editing
  • Over-expression knock-ins
preclinical-CRO-services-tier-1-icon.png

STEP 1

Project design

Our experts review your project requirements and provide consultation before onboarding. Choose from our catalogue of parental cell lines or provide your own including iPSCs, primary T-cells, and polyploidy cell lines.

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STEP 2

Project engineering

We optimize reagents and transfection protocols, then use automation and machine learning for single-cell dilution. Clones are screened with sequencing so that optimal clones are banked and delivered.

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STEP 3

Project delivered

Project updates are provided at regular intervals with validation and QC performed throughout and prior to shipping the final clone and parental line alongside the full data pack.

Learn about our services

knock-in-base-editing252x252

Knock-ins and base editing strategies

Complex modifications scalable through automation

Wherever you stand on the intersection of scale and complexity, we can help you move your research forward quickly. We open new possibilities via knock-in projects and the Pin-point™ base editing platform.

Knock-ins

  • Point mutation: Single Nucleotide Polymorphism (SNP)
  • Tag / Reporter knock-in
    • Fluorescent tags
    • His, Myc, or FLAG
    • Nano-Glo® HiBiT (Promega), LgBiT (Promega)
    • Defined N- or C-terminal insert location
  • Inducible expression systems
  • Translocation
  • Landing pad
  • Small targeted genomic changes between 1bp and ≤66bp
  • Gene overexpression
  • Large genomic insertions of up to ~10kb (random integration)
  • Large knock-in: Large genomic insertions of up to ~10kb (targeted locus)
  • Activation (CRISPRa) or silencing (CRISPRi) of gene of interest at endogenous locus
Knock-in strategy Main uses Key advantages
Single-stranded oligodeoxynucleotide (ssODN) donors Small targeted genomic changes between 1bp and 66bp

High KI efficiencies increased chance of homozygous clone recovery (2 - 3N)

Shorter project timelines

Scarless editing with ssODN donors Only mutation of interest introduced
Pin-point base editing platform Single base, predictable genomic changes

High KI efficiencies increased chance of homozygous clone recovery (>3N)

Multiplex editing

Plasmid donors Large genomic insertions (targeted or random integration) of up to ~ 10kb Can introduce a large variety of large cargo into a precise genomic location
Lentivirus Activation (CRISPRa) or silencing (CRISPRi) of gene of interest at endogenous locus

Not reliant on gRNA availability

Shorter project timelines

Gene overexpression Different levels of gene expression possible

 

Contact us


Related content

Blog

Homology-directed repair with a DNA donor oligo: considerations for successful HDR experimental design

Learn more

Blog

Homology-directed repair with a plasmid donor: considerations for successful HDR experimental design

Learn more

Complex modifications scalable through automation

Wherever you stand on the intersection of scale and complexity, we can help you move your research forward quickly. We open new possibilities via knock-in projects and the Pin-point™ base editing platform.

Knock-ins

  • Point mutation: Single Nucleotide Polymorphism (SNP)
  • Tag / Reporter knock-in
    • Fluorescent tags
    • His, Myc, or FLAG
    • Nano-Glo® HiBiT (Promega), LgBiT (Promega)
    • Defined N- or C-terminal insert location
  • Inducible expression systems
  • Translocation
  • Landing pad
  • Small targeted genomic changes between 1bp and ≤66bp
  • Gene overexpression
  • Large genomic insertions of up to ~10kb (random integration)
  • Large knock-in: Large genomic insertions of up to ~10kb (targeted locus)
  • Activation (CRISPRa) or silencing (CRISPRi) of gene of interest at endogenous locus
Knock-in strategy Main uses Key advantages
Single-stranded oligodeoxynucleotide (ssODN) donors Small targeted genomic changes between 1bp and 66bp

High KI efficiencies increased chance of homozygous clone recovery (2 - 3N)

Shorter project timelines

Scarless editing with ssODN donors Only mutation of interest introduced
Pin-point base editing platform Single base, predictable genomic changes

High KI efficiencies increased chance of homozygous clone recovery (>3N)

Multiplex editing

Plasmid donors Large genomic insertions (targeted or random integration) of up to ~ 10kb Can introduce a large variety of large cargo into a precise genomic location
Lentivirus Activation (CRISPRa) or silencing (CRISPRi) of gene of interest at endogenous locus

Not reliant on gRNA availability

Shorter project timelines

Gene overexpression Different levels of gene expression possible

 

Contact us


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knockout-252x252

Knockouts

Generate the right modification in the right background

Save time and resources while you focus on other work with more than 200 parental cell lines from around 20 tissue types or provide your own cell line for onboarding to our conditions.

Knockouts

  • Single knockout
  • Double knockout
  • Small defined deletion
  • Large genomic deletion

Customers can choose from one of our in-house cell lines or provide a cell line to onboard. During the onboarding process, we perform mycoplasma and sterility testing, as well as assess transfectability and single-cell dilution growth characteristics, where applicable.

In parallel with the cell line assessment phase, we also design and evaluate the reagents to be used in the manufacturing process.

During the cell line engineering phase, our team performs the desired edit(s) defined in the statement of work. Throughout the process, our Project Management team provides regular updates and will contact you promptly if any issue or complication should arise during the manufacturing process.

After manufacturing is complete, the cell line is validated for the desired edit. We validate at the genomic level with Sanger sequencing as standard and for our reporter cell lines we provide a functional readout that verifies reporter expression.

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Generating a clonal HAP1LIG4(-) Cas9(+) cell line – an expert interview

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SVEP1 as a regulator of GPCR-mediated vasoconstriction

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Considerations for engineering a successful knockout cell line generation

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Conditional knockout generation using targeted exon excision and synthetic introns

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Clonal cell lines or pool cell populations? Choosing the right solution to help avoid inconsistent results.

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Contact us

Generate the right modification in the right background

Save time and resources while you focus on other work with more than 200 parental cell lines from around 20 tissue types or provide your own cell line for onboarding to our conditions.

Knockouts

  • Single knockout
  • Double knockout
  • Small defined deletion
  • Large genomic deletion

Customers can choose from one of our in-house cell lines or provide a cell line to onboard. During the onboarding process, we perform mycoplasma and sterility testing, as well as assess transfectability and single-cell dilution growth characteristics, where applicable.

In parallel with the cell line assessment phase, we also design and evaluate the reagents to be used in the manufacturing process.

During the cell line engineering phase, our team performs the desired edit(s) defined in the statement of work. Throughout the process, our Project Management team provides regular updates and will contact you promptly if any issue or complication should arise during the manufacturing process.

After manufacturing is complete, the cell line is validated for the desired edit. We validate at the genomic level with Sanger sequencing as standard and for our reporter cell lines we provide a functional readout that verifies reporter expression.

Related content 

White paper

Generating a clonal HAP1LIG4(-) Cas9(+) cell line – an expert interview

Learn more

Publication review

SVEP1 as a regulator of GPCR-mediated vasoconstriction

Learn more

Blog

Considerations for engineering a successful knockout cell line generation

Learn more

White paper

Conditional knockout generation using targeted exon excision and synthetic introns

Learn more

Blog

Clonal cell lines or pool cell populations? Choosing the right solution to help avoid inconsistent results.

Learn more
Contact us
ipscs-252x252

iPSCs

Tackling disease with iPSCs and genome editing

Our custom cell line engineering services are an efficient platform to edit complex pluripotent stem cells for disease modelling to support a variety of genetic variations.

At Revvity, we have successfully generated over 50 genotypes, achieving differentiation into all three germ layers. Our projects span a range of genetic modifications, including homozygous and heterozygous SNPs, reporter insertions, and gene knockouts.

iPSC cell editing:

  • Single knockout
  • Point mutation (SNP) knock-in
  • Tag / Reporter knock-in
  • Large knock-in

Our iPSC engineering projects can be designed in stages:

  • Step 1: iPSC generation, provided by the customer
  • Step 2: Characterization
  • Step 3: Gene Engineering, including 
    • Point Mutations
    • Gene Knock-out
    • Reporter alleles
  • Step 4: Verification (as optional):
    • Pluripotency
    • Marker expression
    • Karyotyping
       
Contact us

Related content

Blog

Gene manipulation in iPSCs research

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Tackling disease with iPSCs and genome editing

Our custom cell line engineering services are an efficient platform to edit complex pluripotent stem cells for disease modelling to support a variety of genetic variations.

At Revvity, we have successfully generated over 50 genotypes, achieving differentiation into all three germ layers. Our projects span a range of genetic modifications, including homozygous and heterozygous SNPs, reporter insertions, and gene knockouts.

iPSC cell editing:

  • Single knockout
  • Point mutation (SNP) knock-in
  • Tag / Reporter knock-in
  • Large knock-in

Our iPSC engineering projects can be designed in stages:

  • Step 1: iPSC generation, provided by the customer
  • Step 2: Characterization
  • Step 3: Gene Engineering, including 
    • Point Mutations
    • Gene Knock-out
    • Reporter alleles
  • Step 4: Verification (as optional):
    • Pluripotency
    • Marker expression
    • Karyotyping
       
Contact us

Related content

Blog

Gene manipulation in iPSCs research

Learn more
functional-assay-add-ons-252x252

Functional assay add-ons

Expand your engineered cell model with industry-leading screening projects. Use your custom cell line to power functional genomics or cell panel screening assays.

Or, with the cell line engineering teach, achieve even more with the ability to tailor our services with a full suite of add-ons.

  • Delivery of additional clones,
  • Delivery of the edited pool for standard knockout projects
  • qRT-PCR for cDNA cassette knock-ins
  • Nano-Glo® HiBiT (Promega) and NanoLuc® (Promega) tag assessment
  • High content imaging for reporter validation
  • Flow cytometry readouts
  • Supernatant protein analytics with HTRF™, AlphaLISA™ and BioLegend™ LEGENDPlex™ technologies
     
Contact us

Expand your engineered cell model with industry-leading screening projects. Use your custom cell line to power functional genomics or cell panel screening assays.

Or, with the cell line engineering teach, achieve even more with the ability to tailor our services with a full suite of add-ons.

  • Delivery of additional clones,
  • Delivery of the edited pool for standard knockout projects
  • qRT-PCR for cDNA cassette knock-ins
  • Nano-Glo® HiBiT (Promega) and NanoLuc® (Promega) tag assessment
  • High content imaging for reporter validation
  • Flow cytometry readouts
  • Supernatant protein analytics with HTRF™, AlphaLISA™ and BioLegend™ LEGENDPlex™ technologies
     
Contact us
licensing-252x252

Licensing

Revvity has agreements in place with several licensors to work with an extensive catalogue of cell line backgrounds. Additionally, we may be able to support clients in accessing further cell lines.

Knock-ins

*Products that have utilized CRISPR Cas9 systems and methodologies to knock-in a gene, and their use, may be the subject of one or more of the following patents and applications controlled by Sigma-Aldrich Co. LLC (SIGMA): Patent applications and issued patents that entered their respective National Stage from PCT International Pub. No. WO 2014/089290, including, but not limited to, the following, and substitutions, divisions, continuations, continuations-in-part, reissues, re-examinations, and extensions thereof: Australia Patent Nos. 2013355214; 2017204031; and 2018229489; Canada Patent Nos. 2,891,347 and 2,977,152; China Patent No. CN105142669; European Patent Nos. EP 2 928 496 B1; EP 3 138 910 B1, 3 138 911 B1, EP 3 138 912 B1, EP 3 360 964 B1, EP 3 363 902 B1; Israel Patent No. IL238856; Singapore Patent No. 11201503824S; South Korea Patent Nos. 10-1844123 and 10-2006880; and U.S. Patent Nos. 10,731,181 and 10,745,716; and U.S. Application Serial Nos. 15/188,927; 15/188,931; and 15/456,204 (the “Patent Rights”).

iPSC editing

Certain drug screening, target validation and toxicity testing methods that utilize in-vitro differentiated disease models may be covered by one or more patents controlled by Evotec International GmbH. Those patents include EP2270196B1, EP1745144B1 and EP3070174B1 and corresponding foreign patents and pending applications. The purchase or transfer of this product is not intended, either expressly or by implication, to grant any right or license to practice under the foregoing patents. Purchasers are advised to contact Evotec International GmbH at info@evotec.com for information regarding a license to practice under such patents.

*Note on inducible cell line projects: Revvity uses the Tet-On 3G inducible expression system for inducible custom engineering projects. This platform is based on the Tet-On® 3G bipartite induction system: a tightly regulated system consisting of an optimized inducible RNA polymerase II promoter (TRE3G), which provides both minimal basal expression and potent activation upon induction with doxycycline. Prior to starting an inducible cell line engineering project, it is the responsibility of the client to provide licensing from Clontech Laboratories for freedom to use this system.

Terms & conditions

All cell line engineering projects are subject to our Terms & Conditions and our Limited Use Label License.

Revvity has agreements in place with several licensors to work with an extensive catalogue of cell line backgrounds. Additionally, we may be able to support clients in accessing further cell lines.

Knock-ins

*Products that have utilized CRISPR Cas9 systems and methodologies to knock-in a gene, and their use, may be the subject of one or more of the following patents and applications controlled by Sigma-Aldrich Co. LLC (SIGMA): Patent applications and issued patents that entered their respective National Stage from PCT International Pub. No. WO 2014/089290, including, but not limited to, the following, and substitutions, divisions, continuations, continuations-in-part, reissues, re-examinations, and extensions thereof: Australia Patent Nos. 2013355214; 2017204031; and 2018229489; Canada Patent Nos. 2,891,347 and 2,977,152; China Patent No. CN105142669; European Patent Nos. EP 2 928 496 B1; EP 3 138 910 B1, 3 138 911 B1, EP 3 138 912 B1, EP 3 360 964 B1, EP 3 363 902 B1; Israel Patent No. IL238856; Singapore Patent No. 11201503824S; South Korea Patent Nos. 10-1844123 and 10-2006880; and U.S. Patent Nos. 10,731,181 and 10,745,716; and U.S. Application Serial Nos. 15/188,927; 15/188,931; and 15/456,204 (the “Patent Rights”).

iPSC editing

Certain drug screening, target validation and toxicity testing methods that utilize in-vitro differentiated disease models may be covered by one or more patents controlled by Evotec International GmbH. Those patents include EP2270196B1, EP1745144B1 and EP3070174B1 and corresponding foreign patents and pending applications. The purchase or transfer of this product is not intended, either expressly or by implication, to grant any right or license to practice under the foregoing patents. Purchasers are advised to contact Evotec International GmbH at info@evotec.com for information regarding a license to practice under such patents.

*Note on inducible cell line projects: Revvity uses the Tet-On 3G inducible expression system for inducible custom engineering projects. This platform is based on the Tet-On® 3G bipartite induction system: a tightly regulated system consisting of an optimized inducible RNA polymerase II promoter (TRE3G), which provides both minimal basal expression and potent activation upon induction with doxycycline. Prior to starting an inducible cell line engineering project, it is the responsibility of the client to provide licensing from Clontech Laboratories for freedom to use this system.

Terms & conditions

All cell line engineering projects are subject to our Terms & Conditions and our Limited Use Label License.

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