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Whitepaper

Conditional knockout generation using targeted exon excision and synthetic introns

Studying essential genes poses a unique challenge because you cannot generate stable knockout cell lines to investigate loss of function.

In this white paper, we discuss the creative strategies that our cell line engineering team has employed combining CRISPR-Cas9 and inducible Cre-Lox technology to create conditional knockout cell lines.

You will learn about:

  • The challenges of studying the effects of the loss of an essential gene
  • Conditional knockout generation using targeted exon excision and synthetic intros
  • The advantages and disadvantages of each approach

For research use only. Not for use in diagnostic procedures.

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Conditional knockout generation using targeted exon excision and synthetic introns

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