Induced pluripotent stem cells (iPSCs) serve as ideal disease models due to their superior biological relevance and isogenic nature, however gene editing in iPSCs can present a unique set of experimental challenges.

Why edit in iPSCs?

Engineered iPSCs often serve as better models of difficult-to-represent diseases or cell types than traditional immortalized cell lines. Researchers edit iPSCs to create isogenic cell models containing key disease-driving mutations to achieve mechanistic understanding, without background genetic variability, of causative relationships between genotype and phenotype.

Essentially, these edited iPSC lines serve as "disease-in-a-dish" models helping researchers to discover novel drug targets with increased predictability of their safety and efficacy.

iPS cell line engineering services

Many labs simply choose to outsource the engineering portion of their research and focus on downstream phenotypic analysis. Trusting your iPS cell line editing work to a dedicated genome engineering CRO can provide significant cost and time savings.

For nearly a decade, our engineering team has successfully delivered thousands of gene editing projects for major drug discovery, biotech and pharma research. Our vast expertise working with iPSCs provides our partners with confidence that their project with be completed accurately and on time.

We offer genome editing services for:

• Knockout (single or multiple)
• Knock-in
• Reporters
• Overexpression

Project workflow

Once the project scope and timeline are defined, partners receive regular updates from their dedicated project manager.