Bioproduction systems
Enhance cell line development with our clinical, licensable bioproduction cell line solution for safer, more efficient biotherapeutic molecule production, ensuring near 100% stability.
CHOSOURCE GS KO
The CHOSOURCE™ GS KO is an established cGMP manufacturing cell line with proven performance and flexibility for the development and manufacturing of biotherapeutics.
ADCC+
CHOSOURCE™ ADCC+ is a glycoengineered CHO-K1 GS KO cell line for the production of afucosylated proteins for enhanced therapeutic activity. Available for commercial and research applications.
TnT Transposon Vector System
The CHOSOURCE™ TnT transposon technology helps streamline cell line development and accelerate biologic development programs. Available for commercial and research applications
Automated cell counters
Providing fast and accurate ways to perform cell count, concentration and cell viability assessments with our automated solutions. Offering brightfield and fixed single or dual fluorescent platforms that can provide results in less than 3 minutes.
Cellometer Ascend Automated Cell Counter
Accelerate your research workflow with the Cellometer Ascend automated cell counter. Our next generation cell counter is packed with advanced functionalities including autofocus, sample slide detection, and automatic result analysis. The Cellometer Ascend accelerates your lab workflow helping to mitigate human error, all while providing a consistent, standardized cell count.
With its revolutionary design, the Cellometer Ascend has elevated accuracy and reliability in cell counting. Plus, its user-friendly Matrix software incorporates an automated and sophisticated image analysis workflow that delivers reliable results in seconds.
Features and benefits of the Cellometer Ascend:
- Cell counts and viability information - dual fluorescence and brightfield imaging assist with increasing accuracy for nuclei and cell counting
- Fast results - size, count, concentration, and viability calculations in <60 seconds
- Count up to 8 samples at a time - choose between a three- or eight-chamber slide
- Multiple fields of view - increased accuracy with the ability to capture two, four, or eight images per sample
- Analysis of various sample types - including cultured cell lines, PBMCs, primary cells, whole blood, and bone marrow
- Small sample volume - as little as 10 µl of cell sample needed
- Favorites feature - customize experiment settings and save commonly used assays
- Built-in predefined protocols - quickly analyze viability, apoptosis, and transfection efficiency
- Pre-loaded cell types - includes saved parameters for over 400 cell types
- 21 CFR Part 11 ready - optional add-on that includes an audit trail, user access control, and digital signature
Cellometer Auto T4 Brightfield Cell Counter
The Cellometer Auto T4 utilizes brightfield imaging and pattern-recognition software to quickly and accurately identify and count individual cells. Cell count, concentration, diameter, and % viability are automatically calculated and reported.
The Cellometer Auto T4 cell counter offers:
- On screen view of individual cell level information
- Ability to capture multiple fields of view for accurate data
- Built-in cell type library
- Count difficult cells (clumpy, irregular-shaped)
- Options for IQ/OQ Validation and GMP/GLP software
Cellaca MX High-throughput Cell Counter
Increase your productivity and streamline your workflow with the Cellaca MX - the high-throughput automated cell counter that changes everything
- Batch samples – run up to 24 samples at a time
- Small sample volume – only 25 µl of cell sample required
- Autofocus – fast autofocus prior to analysis
- Cell based assays – data output at a single cell level enables you to do cell-based assays such as apoptosis, mitochondrial membrane potential, protein expression (including GFP and RFP), and reactive oxygen species (ROS)
- Time course reporting – easily create growth curves with multiple samples at several time points using the customization tools
- Automatic calculation – calculate various data points such as doubling time for individually labeled samples with an easy-to-use interface
- Multiple configurations – choose to add up to five fluorescent filters
- Automation ready – robotic integration ability with optional API
- Configurable reports – add graphs, images, charts, and tables
- Multi-language support – over 7,000 languages available
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21 CFR Part 11 ready – optional add-on that includes audit trail, user access control, and digital signature
Image cytometers
Ensure efficacy with our high-speed automated imaging platforms designed for high-throughput screening. Providing single-cell analysis with 21CRF Part11 compliance software.es.
Celigo Image Cytometer
Celigo is a plate-based benchtop brightfield and fluorescent imaging system designed for whole-well live-cell analysis and cell sample characterization. The Celigo system images and analyzes cells in various types of vessels including 6 – 1536 well plates, T25, T75 flasks, 10 cm dishes, and glass slides without disturbing their natural state.
Individual cell level analysis is easily generated, providing cell level insights unlike ELISA or protein-based assays, and at a faster rate than flow cytometry. A broad range of complex cell-based assays have been optimized for the Celigo cytometer:
- Apoptosis
- Cell cycle
- Fluorescent reporters
- Cytotoxicity
- Label-free proliferation
Rapid whole-well imaging and analysis
- Sensitive whole-well imaging ensures accurate cell population analysis
- Remove non-uniform seeding from the equation
- Accurately detect, image, and count every cell in every well
- Specialized scanning mirrors enable fast, high-quality images
Advanced brightfield imaging and four fluorescent channels
- Proprietary algorithm for simultaneous imaging and label-free cell analysis
- Perform real-time multiplex assays with four fluorescent channels
Convenient workflow designed for biologists
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Multiple object-driven algorithms and a variety of assay-based applications
- Accessible adaptation with easy-to-follow software
- Save customizable experiments as well as default settings
- Built-in gating parameters allow easy data analysis and visualization
- Real-time graphic feedback allows multiple parameters to be measured simultaneously for intuitive analysis
Automation and data management
- Accessible application programming interface (API) for easy automated workflow integration
- Automated microplate handling for kinetic end-point analysis or time-point analysis
Cellaca PLX High-throughput Image Cytometer
The Cellaca PLX image cytometer provides versatile cell analysis ranging from simple cell counts, concentration, and viability readouts, to more complex multiplexed assays, all using only 15-50 µL of sample. The sensitivity of the system allows for the analysis of up to 24 samples using dual fluorescence and brightfield imaging in under 5 minutes, and single sample multiplexing with four channels in 1 minute.
Multiplex panels for immunophenotyping, apoptosis, and fluorescent protein expression shorten the time to downstream processing with Cellaca PLX low fluorescence slides, dedicated reagents, built-in assays, and configurable data reports. The Cellaca PLX features user friendly software, automation compatibility, and is 21 CFR Part 11 ready. Expert support is provided to integrate the system into current workflows to streamline cell line development, cell isolation, gene delivery, and various research applications.
Key features and benefits of the Cellaca PLX:
- Elevated throughput - run up to 24 samples in under 5 minutes using dual fluorescence and brightfield imaging to count both isolated nuclei and cells
- Multiplexing capabilities - shorten time to downstream processing (one minute per sample with four channels) using our custom reagents kits for surface marker, apoptosis, and fluorescent protein analysis
- Small sample volume - as little as 15 µL of cell sample needed
- Intuitive workflows - including a favorites feature for saving customized experiments and commonly used assays with automatic data analysis and reporting
- Automation ready - robotic integration ability with via API
- 21 CFR Part 11 ready - add-on that includes audit trail, user access control, and digital signature
Microplate readers
Validate therapeutic proteins with our innovative multimode detection platform portfolio that enhances safety by enabling effective screening of active clones via protein interaction or immunoassays.
EnVision Nexus マルチモードマイクロプレートリーダー
EnVision Nexus マイクロプレートリーダーは、ハイスループット スクリーニングの新たなスタンダードとなる製品です。堅牢なパフォーマンスと信頼性の高いデータを常に提供します。
あらゆる検出技術にわたって並外れた速度、超高スループット、および最高の感度を備えた EnVision Nexus は、ハイスループット スクリーニングのための革新的なプラットフォームです。
主な特徴：
- 超高速デュアル検出器
- 磁気フィルターアタッチメント
主な検出：
- 吸光度
- 蛍光強度
- 発光
- 時間分解蛍光
- 蛍光偏光
高度な検出：
- HTS alpha
- TRFレーザー
- 超高感度発光
VICTOR Nivo Multimode Microplate Reader
The VICTOR Nivo system is a high-performance filter-based multimode microplate reader equipped with all major detection technologies:
EnVision XCite Multimode Plate Reader
The EnVision™ XCite multimode plate reader provides exceptional sensitivity across all detection technologies, while keeping you flexible with both filter and monochromator based options plus full upgradeability.
Immunoassays
Gain the extensive analytical characterization data needed for therapeutic proteins at every step of their development from lead selection to lead optimization and characterization, including functional activity testing, up to bioprocessing qualification.
Biologics Screening and Characterization Assays
The development of potent and selective biotherapeutics holds significant promise for the treatment of multiple diseases ever since the introduction of the first human protein therapeutic, human insulin derived from recombinant DNA, in 1982.
Impurity detection assays
Monitor the presence of host cell protein impurities with our no-wash, homogeneous assays and ensure the safety of your biological drugs. Capture the presence of host cell DNA impurities with our DNA detection solutions and assess your biologics purity and help meet regulatory compliance.
HTRF CHO Host Cell Protein Detection kit
The CHO Host Cell Protein kit is designed for the quantitative assessment of Chinese Hamster Ovary (CHO) cell contaminants in bioprocess operations.
AlphaLISA HEK 293 Host Cell Protein Detection Kit
The AlphaLISA™ immunoassay kit for HEK 293 Host Cell Protein (HCP) Detection enables the quantitative determination of HEK 293 HCP in cell culture media, and cell supernatants using a homogeneous AlphaLISA assay (no wash steps).
AlphaLISA CHO Host Cell Protein Detection Kit
The AlphaLISA™ immunoassay kit for CHO Host Cell Protein (HCP) Detection enables the quantitative determination of CHO HCP in buffer, cell culture media, and cell supernatants using a homogeneous AlphaLISA assay (no wash steps).
HostDetect CHO PCR DNA Quant Kit
The HostDetect™ CHO PCR DNA Quant Kit is specific for DNA from CHO genome and not subject to detection of human or environment DNA that might be introduced during sample handling.
The reagents utilize sequence-specific primers and TaqMan® probe to amplify the Alu-equivalent gene of CHO genomic DNA for residual host genomic identification. A primer/probe set to detect Internal Control (IC), is also included for monitoring entire process from extraction to real-time PCR. The reagents also use a dUTP/UNG carryover prevention system to avoid contamination of PCR products. For more information, contact: BioprocessQC@revvity.com
Key Highlights:
- Quantify CHO genomic DNA with as little as 0.01 pg per PCR reaction in < 2 hours of PCR
- Internal control detection for process monitoring from sample extraction to PCR
- High specificity: No cross-reactivity with unrelated DNA
- Flexible extracted DNA input volume up to 10 µL per well
- Scalable reaction numbers from 1 to up to 192 per kit
HostDetect HEK293 PCR DNA Quant Kit
The HostDetect™ HEK293 PCR DNA Quant Kit is specific for DNA from HEK293 genome. The reagents utilize sequence-specific primers and TaqMan® probe to amplify the Alu-element of HEK293 genomic DNA for residual host genomic identification. A primer/probe set to detect Internal Control (IC), is also included for monitoring entire process from extraction to real-time PCR. The reagents also use a dUTP/UNG carryover prevention system to avoid contamination of PCR products. For more information, contact: BioprocessQC@revvity.com
Key Highlights:
- Quantify HEK293 genomic DNA with as little as 0.03 pg per PCR reaction in < 2 hours of PCR
- Internal control detection for process monitoring from sample extraction to PCR
- High specificity: No cross-reactivity with unrelated DNA
- Flexible extracted DNA input volume up to 10 µL per well
- Scalable reaction numbers from 1 to up to 192 per kit
HostDetect E.coli PCR DNA Quant Kit
The HostDetect™ E.coli PCR DNA Quant Kit is specific for DNA from E.coli genome. The reagents utilize sequence-specific primers and TaqMan® probe to amplify the 16S ribosomal RNA gene of E.coli genomic DNA for residual host genomic identification. A primer/probe set to detect Internal Control (IC), is also included for monitoring entire process from extraction to real-time PCR. The reagents also use a dUTP/UNG carryover prevention system to avoid contamination of PCR products. For more information, contact: BioprocessQC@revvity.com
Key Highlights:
- Quantify E.coli genomic DNA with as little as 0.03 pg per PCR reaction in < 2 hours of PCR
- Internal control detection for process monitoring from sample extraction to PCR
- High specificity: No cross-reactivity with unrelated DNA
- Flexible extracted DNA input volume up to 10 µL per well
- Scalable reaction numbers from 1 to up to 192 per kit
Protein characterization
Monitor the identity, activity, and functionality of biological drugs with high analytical sensitivity with our microfluidics-based LabChip system, ProteinEXact™ and Protein Clear.
ProteinEXact Assay Reagent Kit
Bring improved analytical sensitivity to your protein quantitation and sizing applications with the ProteinEXact™ assay for the LabChip® GXII Touch™ protein characterization system. The ProteinEXact™ assay enables accurate, high throughput AAV purity characterization for recombinant viral production.
Protein Clear HR Reagent Kit
The LabChip® GXII Touch Protein Clear™ HR assay is designed for the high-resolution protein purity assessment of monoclonal antibodies (mAb) within research and development, enabling the detection and visualization of impurities within a sample, down to 5 ng/μL.
Protein Pico Assay Reagent Kit
The LabChip Pico Protein reagent provides a fast and easy way to analyze protein samples between 14-200 kDa requiring sensitivity equivalent to Silver Stain levels. Protein detection for concentrations as low as 10 pg/ul, with a linear dynamic range of four orders of magnitude.
Custom GMP cell culture reagents
Meet compliance requirements and be confident in your products safety using our GMP portfolio of cell culture reagents and growth supplements for ex vivo cell processing and downstream manufacturing
Cell-Vive GMP cell culture reagents
Cell-Vive GMP cell culture reagents - Manufactured and tested in accordance with USP Chapter <1043>, Ancillary Materials for Cell, Gene, and Tissue-Engineered Products and Ph. Eur. Chapter 5.2.12 in a dedicated GMP facility compliant with ISO 13485:2016.
Cell-Vive GMP Recombinant proteins
Cell-Vive GMP Recombinant proteins - GMP recombinant proteins are ideal for use in expansion, polarization, and differentiation of cells for research and ex vivo cell processing applications. They’re also free of BSA or other equivalent carrier proteins, thus eliminating the risk of introducing nonrelated or undesired effects on experiments
Cell-Vive GMP Ultra-LEAF Functional antibodies
Cell-Vive GMP Ultra-LEAF Functional antibodies - Manufactured and tested in accordance with USP Chapter <1043> with key product specifications such as ultra-low endotoxin level (<0.01 EU/mg), tested negative mycoplasma, manufactured under serum-free conditions, batch-to-batch consistency, and more
Cell line engineering and evaluation services
Helping create the right edited cell line solution to fit your needs with our specialized cell line engineering services, all backed by an extensive portfolio of gene-editing licences and expertise across hundreds of cell lines.
Cell Line Engineering
Project updates are provided at regular intervals with validation and QC performed throughout prior to shipping the final clone and parental line alongside the full data pack.
CHOSOURCE CLE Services
Partner with the right gene editing experts to aid your biotherapeutic development with custom editing of bioproduction cell lines that support your specific manufacturing needs for protein and viral vector therapeutics.
Engineered Cell Lines
Providing an extensive catalog of ready-to-go gene edited cell lines including knockout and knockin models in HAP1 and cancer related cells