Bead Mill Homogenizers
Lab bead mills for sample homogenization, tissue, and cell lysis
The Omni Bead Ruptor bead mill homogenizers are built upon robust and reliable technologies that leverage the power of mechanical shearing to maximize tissue homogenization and cell lysis. These powerful, durable, and versatile bead-beaters boast processing up to 8 m/s and compatibility with a variety of standard sample tube sizes, as well as a cryo-cooling accessory to avoid samples heating during homogenization.
Explore our comprehensive list of sample homogenization protocol snapshots to plan your sample prep.
When comparing several commercially available bead mill homogenizers based on maceration level, nucleic acid quality, quantity, amplification, and DNA shearing to determine which instruments were effective for their sample type, the authors wrote:
"The Bead Ruptor 24 Elite had the highest overall score when disrupting a single, uninfected adult Amblyomma americanum"1
How to design bead mill homogenization experiments video
For research use only. Not for use in diagnostic procedures.
Omni Bead Ruptor Elite bead mill homogenizer
The Omni Bead Ruptor Elite bead mill homogenizer is a reliable workhorse for any labs seeking consistency in their sample prep, starting with sample homogenization and tissue disaggregation. It combines the benefits of power, efficiency, and flexibility in grinding, lysing, and homogenizing tough samples or complex matrices in various tube type formats for a diverse range of downstream -omics applications.
The Omni Bead Ruptor Elite bead mill homogenizer is a reliable workhorse for any labs seeking consistency in their sample prep, starting with sample homogenization and tissue disaggregation. It combines the benefits of power, efficiency, and flexibility in grinding, lysing, and homogenizing tough samples or complex matrices in various tube type formats for a diverse range of downstream -omics applications.
Omni Bead Ruptor 96+ well-plate homogenizer
The Omni Bead Ruptor 96+ well-plate homogenizer is a high-throughput, tabletop bead mill homogenizer that is also compatible with jar-milling, cryogenic milling, and tube bead-beating. The all-in-one unit is a versatile solution for labs looking for a multi-purpose homogenizer for diverse sample applications, not limited to particle size reduction, disaggregation of non-biological and biological samples, and cryo-milling. It has high-throughput capabilities by its ability to efficiently homogenize and process stacks of standard well plates or racks of strip well tubes during processing using its unique well plate adapter system.
The Omni Bead Ruptor 96+ well-plate homogenizer is a high-throughput, tabletop bead mill homogenizer that is also compatible with jar-milling, cryogenic milling, and tube bead-beating. The all-in-one unit is a versatile solution for labs looking for a multi-purpose homogenizer for diverse sample applications, not limited to particle size reduction, disaggregation of non-biological and biological samples, and cryo-milling. It has high-throughput capabilities by its ability to efficiently homogenize and process stacks of standard well plates or racks of strip well tubes during processing using its unique well plate adapter system.
Omni Bead Ruptor 24 bead mill homogenizer
The Omni Bead Ruptor 24 is a user-friendly lab equipment that delivers rapid throughput and flexibility for up to 24 samples in 2 mL tubes per batch, delivering consistent sample disaggregation and addressing workflow bottlenecks compared to manual prep or lower-throughput homogenizers. Preserve your sample integrity by minimizing the time spent in processing and take advantage of our unique bead mill carriage movements for a robust and efficient sample homogenization and tissue/cell lysis into your lab workflows.
The Omni Bead Ruptor 24 is a user-friendly lab equipment that delivers rapid throughput and flexibility for up to 24 samples in 2 mL tubes per batch, delivering consistent sample disaggregation and addressing workflow bottlenecks compared to manual prep or lower-throughput homogenizers. Preserve your sample integrity by minimizing the time spent in processing and take advantage of our unique bead mill carriage movements for a robust and efficient sample homogenization and tissue/cell lysis into your lab workflows.
Omni Bead Ruptor 12 bead mill homogenizer
The Omni Bead Ruptor 12 bead mill homogenizer is uniquely designed for low- to medium-throughput labs who are looking for efficiency while being cost conscious. The unit accommodates up to 12 samples per run when using 2mL tubes; it is also compatible with processing up to 4 samples in 7mL tubes at a time. This tabletop homogenizer will help streamline sample homogenization workflows across multiple lab users, all at an attractive price point.
The Omni Bead Ruptor 12 bead mill homogenizer is uniquely designed for low- to medium-throughput labs who are looking for efficiency while being cost conscious. The unit accommodates up to 12 samples per run when using 2mL tubes; it is also compatible with processing up to 4 samples in 7mL tubes at a time. This tabletop homogenizer will help streamline sample homogenization workflows across multiple lab users, all at an attractive price point.
Omni Bead Ruptor 4 bead mill homogenizer
The Omni Bead Ruptor 4 bead mill homogenizer is our entry-level bead mill homogenizer, offering a quick and simple solution for cost-conscious labs looking to leverage automation-enabled sample homogenization but doesn’t require anything more than a few tubes at a time. It is a popular unit for labs that are starting their transition from more manual methods to automation-enabled bead mill homogenization to increase their workflow efficiency as lab needs develop and throughput increases. This compact unit is capable of processing up to four tubes, for sample volumes starting at 25 µL.
The Omni Bead Ruptor 4 bead mill homogenizer is our entry-level bead mill homogenizer, offering a quick and simple solution for cost-conscious labs looking to leverage automation-enabled sample homogenization but doesn’t require anything more than a few tubes at a time. It is a popular unit for labs that are starting their transition from more manual methods to automation-enabled bead mill homogenization to increase their workflow efficiency as lab needs develop and throughput increases. This compact unit is capable of processing up to four tubes, for sample volumes starting at 25 µL.
Omni Bead Ruptor cryo cooling unit
The Omni Bead Ruptor cryo cooling unit helps protect heat-sensitive samples during homogenization by maintaining a constant processing temperature and countering the heat generated as part of the bead-milling process. The unit is compatible with the Omni Bead Ruptor Elite bead mill homogenizer and operates by passing chilled air into the processing chamber to dissipate heat from across the sample tubes, better protecting heat-sensitive analytes for downstream processing. It has adjustable cooling rates and is compatible with both liquid nitrogen (preferred method) or dry ice with ethanol. In conjunction with the homogenizer, the unit is compatible with carriages that accommodate tube sizes < 7 mL, but not compatible with the 48 position 2mL carriage system.
The Omni Bead Ruptor cryo cooling unit helps protect heat-sensitive samples during homogenization by maintaining a constant processing temperature and countering the heat generated as part of the bead-milling process. The unit is compatible with the Omni Bead Ruptor Elite bead mill homogenizer and operates by passing chilled air into the processing chamber to dissipate heat from across the sample tubes, better protecting heat-sensitive analytes for downstream processing. It has adjustable cooling rates and is compatible with both liquid nitrogen (preferred method) or dry ice with ethanol. In conjunction with the homogenizer, the unit is compatible with carriages that accommodate tube sizes < 7 mL, but not compatible with the 48 position 2mL carriage system.
"The [Omni] Bead Ruptor uses a complex motion which we find highly effective. In the past, we have used other types of oscillating machines which have a back-and-forth motion along one dimension which can be a problem with certain sample volumes, such that the sample, beads plus yeast plus buffer, stays in essentially the same place, while the tube oscillates around it."2
We offer the Omni Bead Ruptor Elite™ bead mill homogenizers, compatible with our BR Cryo-cooling unit to help with temperature-sensitive analytes such as RNA. For labs looking for flexibility in throughput and well-plate compatibility, the Omni Bead Ruptor 96+ well-plate homogenizer implements bead-milling technology for well-plates, larger milling jars for cryo-milling, and standard lab tubes. For labs just switching from manual methods and needing lower throughput in mostly 2 mL tubes, we offer the just as reliable Omni Bead Ruptor 24, BR 12, and BR 4 for labs starting out on their journey with automation-enabled sample homogenization.
Explore our Bead Mill accessories, including Omni Bead Ruptor Elite accessories or Omni Bead Ruptor 96+ accessories.
We also offer bead mill consumables and bulk tubes, caps, and well-plates.
"In this study, we demonstrated that processing of PCNL-collected kidney stones via BB [bead beating] provided a statistically significantly higher rate of microbial detection compared to the traditional MP [mortar and pestle] method."3
Homogenization bead mix consumables, homogenizer accessories, and automation
Featured resources
References:
- Amanda M Jones, Marshall T Van de Wyngaerde, Erika T Machtinger, Edwin G Rajotte, Thomas C Baker, Choice of Laboratory Tissue Homogenizers Matters When Recovering Nucleic Acid From Medically Important Ticks, Journal of Medical Entomology, Volume 57, Issue 4, July 2020, Pages 1221–1227, https://doi.org/10.1093/jme/tjaa006
- Honey, S., & Futcher, B. (2025). A Trizol-Beadbeater RNA extraction method for yeast, and comparison to Novogene RNA extraction. bioRxiv : the preprint server for biology, 2025.07.30.667760.
- On, T. A., Anwar, F., Chien, A. L., Hsu, C.-H., Vedantam, G., Lainhart, W. D., & Tzou, D. T. (2025). Bead beating demonstrates enhanced bacterial detection in kidney stone culture compared to traditional mortar-pestle processing. Microbiology spectrum, 13(8), e0088925. https://doi.org/10.1128/spectrum.00889-25
