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Whitepaper Icon   Whitepaper
Cell painting - a cellular imaging and machine learning approach to drug discovery
Cell painting solutions from Revvity offer powerful phenotypic high-content screening methods that help to accelerate drug discovery by delivering more predictive data.
Article Icon   Article
Tackling Huntington's disease from all angles
Huntington's Disease research to better characterize early stages of the disease and discover new treatment therapies, while lending support to HD patients and families.
Application Note Icon   Application Note
Characterizing compounds acting on β-arrestin2 coupled GPCRs
This note demonstrates that the kit enables the detection of the cellular interaction between endogenous β-arrestin2 and AP2 proteins for all types of GPCR/β-arrestin interactions, and mediated by all classes of GPCR ligands.
Application Note Icon   Application Note
Uncover the full potential of PROTACs with a no-wash HTRF platform
This note describes a method for in-depth characterization of PROTAC®s with a no-wash platform comprising biochemical and cell-based HTRF assays, using BRD4 as a case study.
Application Note Icon   Application Note
Using IP1 assays to study FGFR mediated pathways for cancer drug research
Detection of IP1 accumulation was achieved using either a no wash Revvity HTRF or AlphaLISA kits. These assays enable the rapid and accurate measurement of the activation status of intracellular downstream key enzymes and second messengers
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Better microplates means better results
Microplates for Research
Application Note Icon   Application Note
Optimization and pharmacological validation of wild type beta-arrestin 2 plasmid transfection.
In this note, we cover the best practices and elements that can be monitored and tested to achieve an effective transfection with the HTRF Wild Type (WT) Beta-arrestin 2 Plasmid and improve the assay window of between 10% and 100+%.
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Proliferation and cell death analyses of 3D cultures using Revvity CellCarrier Spheroid ULA microplates and ATPlite 3D products.
In the process of developing new therapeutic molecules, toxicity – whether it is to be avoided or whether it is desired – is an important feature to consider as early as possible in the development flow.
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Sensitive detection of GPCR activation in various cellular models, based on ERK1/2 phosphorylation
This application note demonstrates how the Advanced Phospho-ERK1/2 (Thr202/ Tyr204) kit is suitable for ERK signaling pathway investigations mediated by GPCR stimulation with pharmacological compounds.
Guide Icon   Guide
Get your free HTRF™ guide
This technical brochure reviews the general principles of HTRF and the associated Tag-lite technology as well as discuss ways these technologies have been applied in drug discovery, biotherapeutics, and fundamental research in therapeutic areas such as Oncology, CNS, and Metabolic and Immune Disorders.
Application Note Icon   Application Note
Highly specific tools for β-arrestin monitoring in various cells
This application note demonstrates the specificity of the HTRF total β-arrestin 1 and HTRF total β-arrestin 2 kits for their targeted arrestin.
Flyer Icon   Flyer
Microplates for Cell Culture
Revvity’s CulturPlates and PhenoPlates are specifically designed to promote cell attachment and growth. These microplates are appropriate for not only cell culture, but also imaging or fluorescence and luminescence assays.
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