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  • プラットフォームと自動化
  • イメージング
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  • In Vivo Imaging Instruments
  • IVIS Lumina X5 Imaging System

IVIS Lumina X5 Imaging System

High-Sensitivity Optical Meets High-Resolution X-ray

The IVIS™ Lumina X5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence with high-resolution x-ray into a compact system that fits on your benchtop. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data- and answers- on anatomical and molecular aspects of disease.

For research use only. Not for use in diagnostic procedures.
Part #: CLS148590
Imaging Modality:
2D Bioluminescence, 2D Fluorescence, X-ray
Request more information Request a quote
IVIS Lumina X5 2D optical imaging system
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
IVIS Lumina X5 2D optical imaging system
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
Video Play Button
IVIS Lumina X5 Imaging System
IVIS Lumina X5 2D optical imaging system
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
Video Play Button
IVIS Lumina X5 2D optical imaging system
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
IVIS® Lumina S5 high throughput, high sensitivity optical in vivo imaging system with integrated x-ray.
IVIS Lumina X5 Imaging System
IVIS Lumina X5 2D optical imaging system
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
IVIS Lumina X5 2D optical imaging system
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
Video Play Button
Request a quote Request more information
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Product variant

2D Bioluminescence, 2D Fluorescence, X-ray
Imaging Modality: 2D Bioluminescence, 2D Fluorescence, X-ray
Part #: CLS148590
Request information

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Product information

  • Overview
  • Specifications
  • Image gallery
  • References

Overview

The IVIS Lumina X5 has all the capabilities of the IVIS Lumina S5 imaging system with integrated industry leading high-resolution x-ray for greater detail. The IVIS Lumina X5 also includes state of the art spectral unmixing features for sensitive multispectral imaging to monitor multiple biological events in the same animal.

High-throughput Optical and X-ray Imaging – No Compromise

The IVIS Lumina X5 integrates a next generation 1 inch CCD camera into our benchtop instrument providing a high throughput 20 x 20 cm FOV sufficient for imaging 5 mice at a time with bioluminescence and fluorescence. Moreover, the large, independently deployed scintillator facilitates X-ray acquisitions of 5 mice and larger rodents up to 500-600 grams with seamless, accurate overlay onto the optical image at any field of view.

As with other IVIS Lumina systems, this instrument is equipped with 26 filters tunable to image fluorescent sources that emit from green to near-infrared. Novel illumination technology effectively increases fluorescent transmission through 900 nm. Additionally, the IVIS Lumina X5 incorporates Revvity's patented Compute Pure Spectrum (CPS) algorithm for spectral library generation software tools to ensure accurate autofluorescence removal, unmixing and fluorophore quantitation.

Standard on all IVIS instruments, absolute calibration affords consistent and reproducible results independent of magnification, filter selection from one instrument to any another IVIS instrument within an organization or around the world.

Industry Leading X-ray Resolution

The IVIS Lumina X5 is equipped with a microfocus X-ray source and geometric magnification and when combined, achieve industry leading X-ray resolution in a 2D optical/X-ray system setting a high standard in multimodal 2D imaging resolution. With optical image overlays at every X-ray resolution, never miss underlying anatomical and structural changes. Get more from your data and explore new applications.

IVIS Lumina X5 – A High Throughput Solution

Not only does the IVIS Lumina X5 offer higher throughput via the next generation 1 inch CCD, but it is also compatible with a set of smart animal handling accessories (purchased separately) designed with throughput and safety in mind.

Smart loading trays enable users to pose animals on the benchtop before placing the tray into the IVIS. Fiducials built into the tray allows the software to automatically recognize and draw ROIs providing automated animal identification.

Animal trays are designed with ease of use and user safety in mind. No nose cones are required thus minimizing cleanup. When used with the next generation anesthesia unit (RAS-4), strong vacuum capabilities minimize excess gas from escaping thus preventing exposure of users to anesthetic gas.

Finally, Living Image™ software brings IVIS technology to life by facilitating an intuitive workflow for in vivo optical, X-ray image acquisition, analysis and data organization. The software’s design creates an intuitive, seamless workflow for researchers of all skill levels.

Key Features:

  • High throughput (5 mice) optical and X-ray
  • Increased throughput (10 mice) using optional manifold
  • High resolution, low dose X-ray with optical overlay
  • Supports mouse and rat imaging
  • Compute Pure Spectrum (CPS) spectral unmixing
  • Full fluorescence tunability through the NIR spectrum
  • Unique accessories to streamline workflow, data acquisition and analysis
  • Complimentary Living Image software licenses are provided with the IVIS systems and upon request

Specifications

Dimensions 48.26 cm (W) x 116.84 cm (H)
Brand
IVIS
Imaging Modality
2D Bioluminescence
2D Fluorescence
X-ray
Unit Size
1 unit

Image gallery

X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
IVIS Lumina X5 Imaging System
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
IVIS Lumina X5 Imaging System
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5
X-ray image of knee with bioluminescent overlay showing signal localization and intensity
Bioluminescent and fluorescent imaging of 4T1-Red-Fluc Cells knee metastasis using IVIS Lumina X5
Cranium of control animal imaged using the IVIS Lumina X5
Bioware® Brite cells 4T1-Red-FLuc knee metastasis showing X-ray imaging of injected knee using IVIS Lumina X5

References

  • Zhou et al (2021). Dipeptidyl Peptidase-4 modulates Long-chain Acyl-CoA synthetase 4 to Promote Lipid Peroxidation and Regulate Ferroptosis in Pancreatic Cancer. Res Square. https://doi.org/10.21203/rs.3.rs-173980/v1
  • Rupp et al (2021). Therapeutic potential of Fingolimod in triple negative breast cancer preclinical models. Translational Oncology. 14(1): 100926. https://doi.org/10.1016/j.tranon.2020.100926
  • Jiang et al (2020). Combined Treatment With CCR1-Overexpressing Mesenchymal Stem Cells and CCL7 Enhances Engraftment and Promotes the Recovery of Simulated Birth Injury-Induced Stress Urinary Incontinence in Rats. Fontiers in Surgery. 7:40. https://dx.doi.org/10.3389%2Ffsurg.2020.00040
  • Trikha et al (2020). Inhibition of Angiotensin Converting Enzyme Impairs Anti-staphylococcal Immune Function in a Preclinical Model of Implant Infection. Front. Immunol. https://doi.org/10.3389/fimmu.2020.01919
  • Brandon et al (2020). Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice. Sci Reports. 10: 10799. https://doi.org/10.1038/s41598-020-67533-1
  • Kelley et al (2020). In vivo Mouse Model of Spinal Implant Infection. Medicine. https://dx.doi.org/10.3791/60560
  • Lefeuvre et al (2020). Effects of topical corticosteroids and lidocaine on Borrelia burgdorferi sensu lato in mouse skin: potential impact to human clinical trials. Sci Reports. 10: 10552. https://doi.org/10.1038/s41598-020-67440-5
  • Liang et al (2019). Idarubicin-loaded methoxy poly(ethylene glycol)-b-poly(l-lactide-co-glycolide) nanoparticles for enhancing cellular uptake and promoting antileukemia activity. Int J Nanomedicine. 14: 543–556. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333394/
  • Karches et al (2019). Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy. Translational Cancer Mechanisms and Therapy. https://doi.org/10.1158/1078-0432.CCR-18-3927

Resources

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  • Application Note (4)
  • Article (1)
  • Brochure (2)
  • Case Study (3)
  • eBook (2)
  • Flyer (2)
  • Infographic (8)
  • Literature - Publication Review (1)
  • Product Note (1)
  • Scientific Poster (15)
  • Technical Note (4)
  • Whitepaper (1)
37-42 of 44 Resources
Technical Note Icon
Technical Note
Subtracting background ROI from the measurement ROIs when performing fluorescence quantitative analysis
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Whitepaper
The role of in vivo imaging in drug discovery and development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time...

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Case Study
Tracking neuroinflammation using transgenic mouse models and optical imaging

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease for which there is no cure. Another lethal brain disease...

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Whitepaper
Understanding the ‘how’ and ‘why’ of spectral unmixing

In vivo fluorescence imaging displays a very broad utility and has become a well-established modality for functional imaging in...

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Case Study
Using IVIS optical imaging of CRISPR/Cas9 engineered adipose tissue to study obesity prevention

Obesity is a global epidemic that is the fifth leading cause of death worldwide and in the US alone, nearly 85% of adults are...

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Infographic Icon
Infographic
Why 3D: stripping complexity out of multi-dimensional cell models

Researchers are turning to 3D cell cultures, microtissues, and organoids to bridge the translational gap between 2D cell cultures...

Learn more

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