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Test of Biomarker of Fabry Disease (Lyso-GL-3)

Test code: LB

Test Inquiry

Test code: LB

Test Inquiry

Test of Biomarker of Fabry Disease (Lyso-GL-3)

Detecting Biomarker of Fabry Disease (Lyso-GL-3) by tandem mass spectrometry.

View test information

Test Code	LB
Test Summary	Detecting Biomarker of Fabry Disease (Lyso-GL-3) by tandem mass spectrometry.
Turn Around Time	7 days
Acceptable Sample Types	Dried Blood Spots
NY Approved	No

*TAT starts after the sample and all required sample information is received at the processing laboratory.

**The CPT codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association, and are provided for informational purposes only. CPT coding is the sole responsibility of the billing party.

This testing service has not been cleared or approved by the U.S. Food and Drug Administration. Testing services may not be licensed in accordance with the laws in all countries. The availability of specific test offerings is dependent upon laboratory location.

Test code: LB

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This test is not available in your region Japan, please select your nearest laboratory to request more information.

Test Inquiry

Test information

Test description

This test is used to monitor the levels of globotriaosylsphingosine (Lyso-GL-3) for disease progression and/or treatment response in individuals with Fabry disease.

Indications for testing

This test may be appropriate for diagnosing and monitoring disease progression and/or treatment response in individuals with Fabry disease.

Condition description

Fabry disease is a lysosomal storage disorder with a wide spectrum of symptoms ranging from mild cases in females, to severe cases in classically affected hemizygous males. Symptoms may include abdominal and joint pain, vascular lesions and corneal abnormalities. Neurological symptoms include autonomic dysfunction and burning sensation or numbness in the extremities. Fabry disease affects an estimated 1 in 40,000 to 1 in 60,000 males. The prevalence is unknown in females.

Test methods and limitations

Tandem mass spectrometry analysis can be coupled with liquid chromatography, a technique referred to as LC-MS/MS. In this methodology, chromatography is used to separate analytes of interest prior to measurement by the mass spectrometer. This separation reduces interference from matrix components and can also allow for the measurement of analytes that have the same mass (isobaric species), thereby improving analytical specificity compared to MS/MS.

Detailed sample requirements

Dried Blood Spots

Test Details Page
Collection Container(s)	Dried blood spot card
Collection	Follow kit instructions. Briefly, allow blood to saturate the card until indicated areas are filled and blood has soaked through the card. Air dry the card at ambient temperature for at least 3 hours. NBS: Please contact Revvity Omics to request the StepOne^® kit. Gene Sequencing: Please contact Revvity Omics to request the DBS collection kit. For pre-punched DBS: The required minimum is 6 punches
Sample Condition	Follow the instructions provided with the collection set. Store the dried blood at ambient temperature for up to two days. If the specimen cannot be sent as soon as it is dry, the filter paper should be placed in a sealable plastic bag and stored in a refrigerator (≤ 8°C) or preferably in a freezer.
Shipping	Follow kit instructions. Double bag and ship overnight at ambient temperature.

How To Order

Step 1

Choose Your Test

Select the correct test for your patient, and download and fill out the Clinical Genomics test requisition form.

Step 2

Collect Sample

Obtain a sample for testing from the patient using one of the provided Revvity Omics test packs.

Step 3

Send Samples

Send samples and all required forms back to Revvity for processing using pre-paid shipping label.

How can we help you?

We are here to answer your questions.

Revvity Sites Globally

Test of Biomarker of Fabry Disease (Lyso-GL-3)

Test of Biomarker of Fabry Disease (Lyso-GL-3)

Test of Biomarker of Fabry Disease (Lyso-GL-3)

About this test

Specifications

Test information

Test description

Indications for testing

Condition description

Test methods and limitations

Detailed sample requirements

Dried Blood Spots

How To Order

Choose Your Test

Collect Sample

Send Samples

How can we help you?

Revvity Sites Globally

Test of Biomarker of Fabry Disease (Lyso-GL-3)

Test of Biomarker of Fabry Disease (Lyso-GL-3)

Test of Biomarker of Fabry Disease (Lyso-GL-3)

About this test

Specifications

Revvity Sites Globally

Test information

Test description

Indications for testing

Condition description

Test methods and limitations

Detailed sample requirements

Dried Blood Spots

How To Order

Choose Your Test

Collect Sample

Send Samples

1. Build Your Custom Panel

2. Complete and print the test requisition

3. Collect and Send Patient Sample

How can we help you?