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Whitepaper
Research spotlight: new therapeutic targets focusing on aberrant lipid metabolism in Alzheimer’s disease
This whitepaper explores new therapeutic targets focusing on Aberrant Lipid Metabolism in Alzheimer's Disease
Article
Tackling Huntington's disease from all angles
Huntington's Disease research to better characterize early stages of the disease and discover new treatment therapies, while lending support to HD patients and families.
Whitepaper
Accelerating immuno-oncology therapeutic development: choosing the best preclinical model
Selecting the appropriate preclinical model for immuno-oncology therapeutic development.
Whitepaper
Dual NIR imaging of β-Amyloid plaques and Tau tangles provides potential insights into Alzheimer’s disease
The use of Dual NIR Imaging of β-Amyloid Plaques and Tau Tangles to provide Potential Insights into Alzheimer’s Disease
Literature - Publication Review
In vivo imaging of influenza virus infection in immunized mice
Using the IVIS® in vivo imaging platform to quantifiy H1N1pmd09-Nluc influenza viral load in mice and demonstrated that human mAb administration has a protective or therapeutic effect in mice challenged with influenza virus.
Literature - Publication Review
Biopolymers Codelivering Engineered T Cells and STING Agonists can Eliminate Heterogenous Tumors
Using the IVIS® Spectrum non-invasive preclinical optical system to quantify tumor-specific T cells responses in NFAT-luciferase transgenic mice.
Whitepaper
Bioluminescence Resonance Energy Transfer (BRET) to monitor protein-protein interactions
The ability to image PPIs in vivo has important implications for a wide variety of biological research endeavors, including drug discovery and molecular medicine.
Case Study
Tracking neuroinflammation using transgenic mouse models and optical imaging
Case study on tracking neuroinflammation using transgenic mouse models and IVIS® optical imaging to better understand neurodegenerative disease and brain injury.
Literature - Publication Review
Inhibiting interleukin 11 signaling reduces and reverses many dangerous effects of NAFLD/NASH in mouse models
Study demonstrating that inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of NASH
Article
Selective targeting of mHTT presents novel therapeutic approach to huntington's disease
Researchers have engineered zinc finger protein transcription factors (ZFP-TFs) to target the pathogenic CAG repeat and selectively lower mHTT as a therapeutic strategy.
Literature - Publication Review
Exploring mechanisms behind alphavirus-induced post-encephalitic parkinsonism
neuroinvasive viruses eliciting neurodegenerative symptoms of post-encephalitic parkinsonism by using bioluminescent or fluorescent recombinant WEEV in an in vivo mouse model
Whitepaper
Deconstructing and leveraging 3D structures of RNAs for novel therapeutics
A research team has engineered degradation-resistant mRNAs which could hold promise for treating various neurodegenerative disorders.
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