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Developing novel tetraubiquitin substrates and AlphaLISA technology to provide next generation deubiquitinase assays
This application note presents novel biochemical DUB assays that use TUBEs to bind to tetraubiquitin substrates of at least three natural linkages. These assays, combined with Revvity’s AlphaLISA™ technology, allow for the measurement of protein interactions and large protein complexes in a no-wash, homogeneous assay.

Detection of human matrix metalloproteinase 9 in complex sample matrices, a comparison of AlphaLISA and colorimetric ELISA immunoassays
This note compares two immunoassay technologies: ELISA (enzyme-linked immunosorbent assay) and AlphaLISA™ (amplified luminescent proximity-based homogeneous assay).

Expert interview: recapitulating the blood-brain barrier using in vitro hiPSC models in drug discovery
Better understand the blood-brain barrier for translational research and drug discovery in neurodegenerative diseases.

Genetically engineered PDX models as patient avatars in preclinical evaluation of acute leukemias
Identifying therapeutic targets using gene silencing techniques in PDX models

Why 3D: stripping complexity out of multi-dimensional cell models
Bridging the gap between 2D Cell cultures and in vivo conditions.

Brightfield and Fluorescent Image Analysis for Screening Applications using the Celigo Adherent Cell Cytometer
Brightfield and Fluorescent Image Analysis for Screening Applications using the Celigo Adherent Cell Cytometer

Cell-mediated cytotoxicity assay by high-throughput direct cell counting in microplates using fluorescence-based image cytometry
Cell-Mediated Cytotoxicity Assay by High-Throughput Direct Cell Counting in Microplates using Fluorescence-Based Image Cytometry

A high-throughput image cytometry-based screening method for the detection of IL2-induced peripheral blood mononuclear cell-mediated cytotoxicity
A high-throughput image cytometry-based screening method for the detection of IL2-induced peripheral blood mononuclear cell-mediated cytotoxicity

Real-time Caspase 3/7 measurement of suspension and adherent cells using the Celigo image cytometer
Real-time Caspase 3/7 measurement of suspension and adherent cells using the Celigo image cytometer

Validating and optimizing single cell sorting of FACS using Celigo image cytometry
Validating and optimizing single cell sorting of FACS using Celigo image cytometry

Impairment of a Distinct Cancer-Associated Fibroblast Population Limits Tumor Growth & Metastasis
Revvity’s workflow solutions used to study different subtypes of fibroblasts and their role in tumor development.

Cellometer Spectrum image cytometer flyer
Flyer summarizing the Cellometer Spectrum image cytometer.


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