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Article
Assessing nanomedicine delivery across the blood-brain barrier using pre-clinical in vivo imaging
Researchers discuss the rationalrationale behind utilizing various pre-clinical in vivo imaging techniques to explore the uptake of custom-designed nanomedicines at different stages of brain cancer.
Application Note
DELFIA VICTOR Immunoassays- How to Optimize Rapid and Simple Immunoassays
In this application note, parameters affecting the performance characteristics of rapid and simple immunoassays have been optimized. These parameters were temperature, concentration of immunocomponents, dynamics (including diffusion), and the quality of immunocomponents.
Application Note
Developing novel tetraubiquitin substrates and AlphaLISA technology to provide next generation deubiquitinase assays
This application note presents novel biochemical DUB assays that use TUBEs to bind to tetraubiquitin substrates of at least three natural linkages. These assays, combined with Revvity’s AlphaLISA™ technology, allow for the measurement of protein interactions and large protein complexes in a no-wash, homogeneous assay.
Application Note
Adaptation of a Bacterial Growth Detection Assay on the VICTOR Nivo for Measurement of Antibiotic Effects
In this application note, the VICTOR® Nivo™ plate reader is used for automated detection of bacterial growth assay to help prevent common issues and to greatly reduce consumables and waste. Learn more.
Application Note
Detection of human matrix metalloproteinase 9 in complex sample matrices, a comparison of AlphaLISA and colorimetric ELISA immunoassays
This note compares two immunoassay technologies: ELISA (enzyme-linked immunosorbent assay) and AlphaLISA™ (amplified luminescent proximity-based homogeneous assay).
Application Note
HMGB1, IL-1β and IL-18 assays used together to discriminate pyroptosis and necroptosis
This application note shows that the release of HMGB1 induced in the context of pyroptosis and necroptosis can be easily monitored with the HTRF® HMGB1 kit.
Application Note
Download your application note on fibrosis characterization
This note describes deep investigations of the molecular mechanisms involved in tissue fibrosis, and occurring in the major effector cell types.
Application Note
Download your application note on nuclear receptor ligand identification with HTRF
This application note illustrates the use of HTRF PPI reagents to easily build robust and convenient biochemical NR/ CoA recruitment assays.
Article
Selective targeting of mHTT presents novel therapeutic approach to huntington's disease
Researchers have engineered zinc finger protein transcription factors (ZFP-TFs) to target the pathogenic CAG repeat and selectively lower mHTT as a therapeutic strategy.
Application Note
Noninvasive tracking of spleen volume in rodents using automated ultrasound imaging
Noninvasive tracking of spleen volume in cancer and lupus murine models using the Vega™ automated, hands-free, high-throughput ultrasound imaging system
Application Note
Best practices for analyzing tumor xenografts
This technical note provides procedures and guidelines for performing HTRF phospho-protein assays on tumor xenografts, with a particular focus on the preparation of tumor lysates and working samples.
Application Note
Download your protocol on CD4 T cells differentiation into Th17 cells
In this application note is reported a protocol for the isolation of mouse naïve CD4+ T-cells and their differentiation into T-Reg and Th-17 cells.
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