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Whitepaper
Relevance of multiparametric screening to drug discovery efforts
This white paper explores the importance of multiparametric screening to drug discovery efforts
Application Note
Monitoring residual HEK293 DNA in AAV-based therapies using the HostDetect HEK293 PCR DNA quant kit
Data behind the development of the HostDetect Hek293 kit that offers a PCR-based approach for quantifying residual host cell DNA
Application Note
Machine-learning prediction of drug mechanism of action from high-content cell painting images
This application note demonstrates how machine-learning and high-content imaging can be applied to predict drug mechanism of actions.
Application Note
Proinflammatory cytokine evaluation from human PBMCs in response to AAV8 peptides
This application note discusses the evaluation of proinflammatory cytokines from human PBMCs in response to AAV8 peptides using HTRF and ELISpot technologies. It highlights the methodology, results, and significance of cytokine profiling in the context of gene therapy.
Product Note
Automated characterization of proteins and nucleic acids
Streamline your slab gel electrophoresis, while providing increased throughput and the data formats required for biotherapeutics and genomics workflows.
Application Note
Characterization of NISTmAb with microfluidic CE-SDS
Application note demonstrating NISTmAb characterization using capillary electrophoresis on the LabChip GXII Touch Protein Characterization System.
Application Note
An evaluation of control analysis system performance between the LabChip GXII and SCIEX PA800 Plus system
In this app note mAbs were evaluated using the Protein Clear™ HR assay and an orthogonal method, the SCIEX® PA800 Plus system.
Literature - Publication Review
SVEP1 as a regulator of GPCR-mediated vasoconstriction
This literature review describes how scientists uncovered multifunctional roles of SVEP1, a known contributor to cardiovascular disease.
Whitepaper
Generating a clonal HAP1LIG4(-) Cas9(+) cell line – an expert interview
An interview with Dr. Gerety, the Sanger Institute on generating a new HAP1 cell line and how it can help advance scientific discovery.
Application Note
Effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in high-content analysis screening experiments
Find out about the effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in HCA screening experiments.
Application Note
Pooled phenotypic CRISPR screening enables the identification of synergistic drug combinations for cancer therapy
This application note demonstrates how a pooled phenotypic CRISPR screening can be used to identify synergistic drug combinations for cancer therapy
Literature - Publication Review
Linking genes to phenotypes with CRISPR screening
Literature review on the multiple CRIPSR screening techniques available for drug discovery and their benefits.
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