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Whitepaper
The role of in vivo imaging in drug discovery and development
Preclinical in vivo imaging helps to ensure that smart choices are made by providing go/no-go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.
Literature - Publication Review
Evaluating a novel nanoparticle platform for controlled liraglutide release in a Type II diabetes mouse model
Optical imaging using the IVIS® Platform to evaluate a novel nanoparticle system for controlled liraglutide release in a diabetic mouse model.
Case Study
Using IVIS optical imaging of CRISPR/Cas9 engineered adipose tissue to study obesity prevention
Assessment of brown fat activation of CRISPR engineered adipose tissue in a mouse model using Revvity's IVIS® optical imaging platform.
Literature - Publication Review
Improving engineered T cell efficacy for treating solid tumors through epigenetic modulation
Researchers used the Opera Phenix® HCS and IVIS® preclicinal imaging system to evaluate engineered T-cells through epigenetic modulation showing the potential of improving the cytotoxic effects on solid tumors.
Case Study
A novel mouse model using optical imaging to detect on-target, off-tumor CAR-T cell toxicity
A Novel Mouse Model Using IVIS® Optical Imaging to Detect On-Target, Off-Tumor CAR-T Cell Toxicity.
Whitepaper
Research spotlight: new therapeutic targets focusing on aberrant lipid metabolism in Alzheimer’s disease
This whitepaper explores new therapeutic targets focusing on Aberrant Lipid Metabolism in Alzheimer's Disease
Literature - Publication Review
In vivo imaging of influenza virus infection in immunized mice
Using the IVIS® in vivo imaging platform to quantifiy H1N1pmd09-Nluc influenza viral load in mice and demonstrated that human mAb administration has a protective or therapeutic effect in mice challenged with influenza virus.
Literature - Publication Review
Biopolymers Codelivering Engineered T Cells and STING Agonists can Eliminate Heterogenous Tumors
Using the IVIS® Spectrum non-invasive preclinical optical system to quantify tumor-specific T cells responses in NFAT-luciferase transgenic mice.
Whitepaper
Bioluminescence Resonance Energy Transfer (BRET) to monitor protein-protein interactions
The ability to image PPIs in vivo has important implications for a wide variety of biological research endeavors, including drug discovery and molecular medicine.
Case Study
Tracking neuroinflammation using transgenic mouse models and optical imaging
Case study on tracking neuroinflammation using transgenic mouse models and IVIS® optical imaging to better understand neurodegenerative disease and brain injury.
Case Study
A novel non-Invasive in vivo tool for the assessment of NASH
Visualizing and quantifying NASH in a preclinical in vivo imaging model using the IVIS Lumina Series III optical and Quantum GX2 microCT imaging systems.
Case Study
Optical and microCT imaging enables noninvasive monitoring of EBV-induced neuroinvasion
Researchers use optical and microCT imaging to noninvasively monitor EBV-induced neuroinvasion in a mouse model.
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