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Case Study
Assessment of MYC-driven progression of small cell lung cancer
Researchers at Huntsman Cancer Center use GEMM and the Quantum microCT system for evaluating small cell lung cancer.
Whitepaper
Dual NIR imaging of β-Amyloid plaques and Tau tangles provides potential insights into Alzheimer’s disease
The use of Dual NIR Imaging of β-Amyloid Plaques and Tau Tangles to provide Potential Insights into Alzheimer’s Disease
Literature - Publication Review
Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma
Researchers used the IVIS Spectrum and IVISbrite D-luciferin substrate to investigate how a spleen-targeted DNA vaccine, delivered via RBC-hitchhiked nanoparticles, effectively induced robust neoantigen specific T cell responses in HCC.
Literature - Publication Review
A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency
Researchers design an adeno-associated virus (AAV) 6 capsid that demonstrates efficiency in lung epithelial cell transduction in a mouse model validated using optical imaging.
Literature - Publication Review
Countering vascular calcification through mitochondrial phosphate transport inhibition in a CKD murine model
Researcher using in vivo imaging to study countering vascular calcification through mitochondrial phosphate transport inhibition in chronic kidney disease.
Literature - Publication Review
Exploring mechanisms behind alphavirus-induced post-encephalitic parkinsonism
neuroinvasive viruses eliciting neurodegenerative symptoms of post-encephalitic parkinsonism by using bioluminescent or fluorescent recombinant WEEV in an in vivo mouse model
Literature - Publication Review
Utility of engineered human Neural Stem Cells (NSCs) expressing varying exon 1 HTT fragments to study Huntington’s disease
Huntington's disease is most commonly caused by an expansion mutation in the CAG trinucleotide repeat within exon 1 of the HTT gene which codes for the protein huntingtin.
Literature - Publication Review
DNA origami elevates the design of multispecific antibodies as cancer therapeutic agents
Publication review highlighting the use of the IVIS™ Lumina X5 optical imaging system and BioLegend Antibodies describe programmable T cell engagers (PTEs), a novel class of agents created with DNA origami, a nanotechnology that allows the precise spatial arrangement of biomolecules. When combined with antibodies, this approach holds great promise to develop specific and effective biomedical nanotherapies for diseases like cancer.
Product Note
VivoJect - Targeted injection of cells and drug therapies
This product note highlights the VivoJect image guided injection system for targeted delivery of cells and therapies
Literature - Publication Review
Tumor-targeting nanoparticles for enhanced PROTAC delivery
This publication review highlights how researchers using the IVIS Lumina III optical imaging system and Cellometer cell counter to study the potential of tumor-targeting nanoparticles to significantly enhance PROTAC delivery.
Brochure
IVIS Spectrum 2 platform - illumination in focus
Discover the next generation in preclinical optical imaging, the IVIS Spectrum 2 and IVIS SpectruCT 2 systems.
Case Study
Temporal tracking of an effective intervention in rodent liver fibrosis
Visualize, track, and quantify progression & regression of liver fibrosis using the Vega® non-invasive 3D ultrasound system.
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