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Article
Busting high-content imaging myths
High-content imaging has become a cornerstone of life science research, providing valuable insights into cellular function and drug responses. However, as with any advanced technology, misconceptions and myths can emerge. In this article, we’ll debunk some of the most common myths surrounding high-content imaging, shedding light on its true strengths and limitations.
Whitepaper
High content screening in three dimensions
This paper provides a recommended workflow for 3D HCS analysis, with a focus on reducing the 3D image analysis time by utilizing High Performance Computing.
Application Note
Phenotypic analysis of hypertrophy in human iPSC-derived cardiomyocytes
Application note describing phenotypic analysis of hypertrophy in human iPSC-derived cardiomyocytes using the Opera Phenix high-content screening system
Literature - Publication Review
Developing a phenotypic in vitro model for progression of liver steatosis
A recent study developed a model of hepatic steatosis in functional human induced pluripotent stem cell-derived hepatocytes (hiPSC-Hep).
Case Study
A workflow to characterize and benchmark human induced pluripotent stem cells
Case study describing a high-content imaging workflow to characterize and benchmark human induced pluripotent stem cells
Technical Note
How to perform successful long term live cell imaging in a high-content analysis system
How to perform successful long term live cell imaging in a high-content analysis system
Literature - Publication Review
Artemisinins target GABAA receptor signaling and impair α cell identity
Artemisinins Target GABA Receptor Signaling and Impair α Cell Identity encouraging α cells to convert into insulin-producing β-like cells.
Literature - Publication Review
Bone morphogenetic protein 8B - a promising therapeutic avenue for NASH treatment
Bone Morphogenetic Protein 8B investigated as a Promising Therapeutic Avenue for NASH Treatment
Case Study
Phenotypic characterization of mitochondria in breast cancer cells using morphology and texture properties
This case study validates the use of STAR morphology and SER texture features to quantifiably characterize mitochondrial morphology and to detect changes induced by drug treatments.
Case Study
High-content analysis of drug-induced oligodendrocyte differentiation promoting remyelination in multiple sclerosis
Case study describing High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis
Application Note
Measuring FRET using the Opera™ Phenix™ high-content screening system
Here, we present a FRET-based high-content screening assay to study the interaction of the anti-apoptotic protein Bcl-XL with the pro-apoptotic protein Bad.
Application Note
A multiparametric live-cell cytotoxicity analysis using the Operetta High-content Analysis System
An in vitro cytotoxicity approach using HepG2 cells, which are used as an effective indicator of the human hepatotoxicity potential of test compounds.
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