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Application Note
Phenotype discrimination using the PhenoVue cell painting and multi-organelle staining kits
In this study, we analyzed the phenotypes induced by a set of 15 reference compounds using both the PhenoVue cell painting kit and the PhenoVue multi-organelle staining kit to compare phenotypic discrimination results of the two assays.
Technical Note
Expanding imaging multiplexing capabilities with PhenoVue Fluor 400LS - Phalloidin
This technical note offers tips and best practices relating to fluorescent signal quality using PhenoVue Fluor 400LS Phalloidin stain.
Application Note
Orthogonal validation of CRISPRCas9 and siRNA generated phenotypes using cell painting
Investigate cell cycle regulation through AURKB, GMNN, and PLK1 proteins. Learn how CRISPR-Cas9 and siRNA techniques, combined with high-content imaging on the Opera Phenix™ Plus, reveal their roles in cell division and genomic stability.
Infographic
Cell painting: from images to innovation
Learn everything you need to know about cell painting, including what it is, how it works, and what you need to get started.
Whitepaper
Cell painting - a cellular imaging and machine learning approach to drug discovery
Cell painting solutions from Revvity offer powerful phenotypic high-content screening methods that help to accelerate drug discovery by delivering more predictive data.
Application Note
Cell painting for phenotypic screening
Application note describing how to set-up a cell painting assay.
Whitepaper
Gene editing of primary immune cells to aid next-generation cellular immunotherapies
Researchers have successfully deployed CRISPRa/i in primary human T cells, offering critical insights into the pathways required for cytokine regulation.
Literature - Publication Review
The impact of pan-KRAS inhibitors on cancer drug discovery
Read how Boehringer Ingelheim generated compounds to target the "undruggable" KRAS pathway with the help of Revvity's preclinical services.
Application Note
2D OncoSignature™ Long-Term Assay: Extending the reach of cell panel screens
This application note describes the development of the 2D OncoSignature™ Long-Term Assay (LTA) drug discovery service.
Application Note
Profiling compound effect on immune cells by combining ImmuSignature assays and LEGENDplex bead-based multiplex protein quantification
Explore Revvity's preclinical services for cell engineering and screening in our ebook.
Brochure
Cell engineering and screening services ebook
Explore Revvity's preclinical services for cell engineering and screening in our ebook.
Application Note
Evaluation of drug selectivity and efficacy using PROTACs in a 3D co-culture spheroid model
The aim of this study was to evaluate the efficacy and selectivity of SJF1528, a pan-EGFR PROTAC, and MS39, a mutant-specific EGFR L858R PROTAC, while exploring the use of both high-content imaging and no-wash HTRF immunoassays in encapsulated 3D spheroid models.
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