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Literature - Publication Review

Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma

Researchers investigated how a spleen-targeted DNA vaccine, delivered via RBC-hitchhiked nanoparticles, effectively induced robust neoantigen specific T cell responses in hepatocellular carcinoma (HCC). This approach not only inhibited tumor growth, but also showed potential for complete tumor regression when combined with anti-PD-1 therapy, offering a promising strategy for personalized immunotherapy in HCC.

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Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma

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