The modulatory effects of A2AR on NMDAR functionality using primary neurons and microglia cultures for potential neuroprotection in Alzheimer’s disease

In neurodegenerative diseases, there remains a continued interest in exploring not only the basic mechanism of how a drug is eliciting a protective effect against symptoms, but also synergistic cellular pathways that may increase the effectiveness of existing therapies. For those impacted by Alzheimer’s Disease (AD), two main types of drugs exist on the market that either modulate the N-methyl D-aspartate ionotropic glutamate receptor (NMDAR) or are Acetylcholinesterase inhibitors (AchEIs). These drugs that act on NMDARs are purposefully designed to be weak negative allosteric modulators to elicit sufficient response without becoming toxic. In this literature review, we examine a recent study where researchers investigated the potential regulation of NMDAR function.

For research use only. Not for use in diagnostic procedures.