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Literature - Publication Review

Linking genes to phenotypes with CRISPR screening

The discovery of the CRISPR-Cas9 system has led to the rapid adoption of gene editing techniques within phvarmaceutical and biotechnology research. As CRISPR-Cas9 approaches appear not to suffer from the variability evident with RNA interference-based gene silencing, this technology is increasingly providing novel and compelling opportunities for drug discovery.

In this article, we explore the various approaches researchers are taking to understand the genetic underpinnings of complex biological pathways using CRISPR screening, including:

  • The evolution of CRISPR screening
  • Pooled CRISPR screens and thier use in complex physiological systems
  • Adaptations for complex disease analysis
  • Arrayed phenotypic CRISPR screening
  • Dual CRISPR screening

For research use only. Not for use in diagnostic procedures.

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Linking genes to phenotypes with CRISPR screening

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