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Application Note

Improved deep-tissue imaging with red-shifted luciferase tumor cell lines

Used in preclinical in vivo research and drug development in areas such as cancer, luciferase reporters provide a simple, sensitive means to measure tumor growth and assess drug efficacy through in vivo bioluminescence imaging. Commonly used firefly luciferase generates relatively low bioluminescent signal making it difficult to detect tumors located deep within tissue.

The application note demonstrates how IVISbrite™ tumor cell lines labeled with red-shifted luciferase (Red F-luc) yields a 100-fold higher signal intensity compared to competitor luciferase labeled cells enabling deeper tissue imaging of tumors.

For research use only. Not for use in diagnostic procedures.

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Improved deep-tissue imaging with red-shifted luciferase tumor cell lines

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