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Application Note
Harness avidity without compromising on pharmacology
Characterize compounds in extra-low affinity interactions
This Note groups protocols and data showing how a Biotin-Streptavidin system can be used to increase the apparent affinity of a protein-protein interaction and make it easy to characterize.
No need to worry about the pharmacology of compounds tested this way: you will also see experiments demonstrating that this avidity-based approach does not impair compound characterization.
Features:
- Apparent affinity of weak interactions enhanced with the Biot-SA system
- Evidence for pharmacological validation
- Kd determination using the avidity approach
For research use only. Not for use in diagnostic procedures.
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Harness avidity without compromising on pharmacology