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Application Note
CRISPRa: Transcriptional upregulation screening with genome-wide CRISPR activation
In this application note, we present a human whole-genome CRISPRa platform and demonstrate its effectiveness in identifying resistance genes complementary to those identified through loss-of-function screening, under vemurafenib cytostatic conditions.
With the ability to enhance transcription by several orders of magnitude, researchers have the opportunity to explore resistance mechanisms based on a CRISPRa-driven gain-of-function platform.
For research use only. Not for use in diagnostic procedures.
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CRISPRa: Transcriptional upregulation screening with genome-wide CRISPR activation