Zephyr Workstations

Achieve peak performance in your genomic workflow: Revvity's optimized, automated solutions are designed to improve the efficiency of your genomic workflows. By providing labs with complete, single-source solutions from sample to analysis, we aim to address the complex challenges associated with genomic analysis. "

This automated solution of the liquid handling workstations and NEXTFLEX ® Rapid XP V2 DNA-Seq kit, combined with NEXTFLEX proprietary normalization beads produces consistent amount of DNA for all samples in a library pool. Thus, shortening the time needed for quantification and pooling preparation for sequencing by up to 3 hours/96 sample. Read this application note to learn how you can automate the NEXTFLEX ® Rapid XP V2 DNA-Seq Kit on a Sciclone ® or Zephyr ® liquid handler to construct normalized, ready-to-sequence DNA-seq libraries while reducing hands-on time and variability.

Illumina® Complete Long Read (ICLR) Prep with Enrichment, Human Kit uses long-read sequencing technology to access areas of the genome that are traditionally challenging to map. ICLR, Enrichment with HCP is aimed for researchers who want to combine the benefits of long-read and short-read sequencing on a single platform. This enables studying complex genetic variations like structural rearrangements and repetitive elements, which can be challenging for short-read sequencing alone. Learn how automating this cutting-edge technology is powering our understanding of genetic diseases, evolution, and human genomic diversity.

For many years it was thought that there were just three types of RNA: mRNA, transfer RNA (tRNA), and ribosomal RNA (rRNA). However, in recent years, researchers have begun to realize that there are many other types which play key roles in cellular processes. Interestingly, deficiencies in mRNA or ncRNA have been linked to certain neurodegenerative and neurodevelopmental disorders. Dr. Jeffrey Kieft, from the University of Colorado School of Medicine, is developing a way to engineer viral RNA and subsequently reduce the rate at which mRNA is destroyed by enzymes in cells. He sees this application as a potentially powerful research tool for neuroscientists, and perhaps even the foundation for therapies of the future.

From Bench to Sequencing within Days With the cost to sequence genomes declining dramatically, scientists and researchers are applying next generation sequencing (NGS) technology to new discoveries and clinical research applications at a rapidly expanding rate. These applications are driving the need for sample preparation workflows that prepare the DNA/RNA libraries prior to sequencing. This growing appetite for new kits plus the demand for higher-throughput solutions often mean that start-up to sequencing can take months. The development of vendor-qualified, automated library protocols solves this growing problem. This scientific brief examines how vendor-qualified automated library protocols are shrinking the time to start sequencing from months to days. It describes how installing a vendor-qualified method eliminates much of the on-site application development, field service, and support work that are required by a custom or unqualified automated method. Case studies demonstrate the meaningful impact of these solutions on NGS application installation and start-up. With over 35-years of experience in automated liquid handing including the Sciclone ® and Zephyr ® NGS workstations, and a pioneer in NGS automation, Revvity has a wide portfolio of NGS library prep automated solutions.

During recent years, long-read, single-molecule DNA sequencing has ascended to become a foundational technology in genomic research. With the ability to provide a more comprehensive view of the genome, the technology has been applied to resolve some of the most challenging areas of human genetics. It also has been effective identifying complex structural variants and analyzing among the first telomere-to-telomere assemblies of whole chromosomes. While long-read sequencing is becoming common in genetic research, it introduces new requirements for sample and DNA library preparation. Discover what you should know about sample and library preparation to improve long-read next generation sequencing (NGS)."