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  • ホーム
  • Products
  • 研究・開発
  • 研究ソリューション
    • ゲノム解析
    • タンパク質解析
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    • 研究ソリューション
  • バイオロジクス
    • Immunoassays Solutions
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    • Safety & Efficacy

Safety & Efficacy

Conduct immunogenicity and pharmacological studies of biotherapeutic candidates

During the development of biological products, comprehensive studies are conducted throughout various stages to evaluate any potential risks and assess their effectiveness.

Preclinical development plays an important role in identifying potential side effects, such as immunotoxicity, that large molecule candidates may pose on the immune system. Additionally, strict regulations are also in place to minimize risks, prioritize safety, and enable the responsible development and approval of biological products.

Our comprehensive suite of tools has been developed to help support researchers in understanding key characteristics of biological drug candidates. This includes tools for investigating immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD), as well as evaluating the immune system response and in vivo metabolism of biologic drugs.

In addition, our informatics solution empowers researchers with the ability to interpret, assess, and predict potential immunogenicity early in the drug discovery workflow. By providing valuable insights, this solution can help to increase success rates of your biotherapeutic development.


For research use only. Not for use in diagnostic procedures.

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Explore our solutions

Biologics immunogenicity and PK/PD In vitro assay
Biologics immunogenicity and PK/PD

The immunogenic potential of biotherapeutic drug molecules can have an effect at any point, from its administration through to metabolism and elimination. Therefore, it is important to understand the impact of immunogenicity upon the PK and PD properties of a large molecule drug.

The characterization of the effect of anti-drug antibodies on the PK is critical. The development of a physiologically relevant PK model in the context of the immunogenicity profile offers significant value to preclinical development.

We offer technology platforms that enable in vitro, ex vivo, and in vivo evaluations to help you understand the immunogenicity of your biologics.

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自動液体分注

当社は40年以上にわたり、ラボでの科学研究の加速をサポートする液体処理ソリューションを提供してきました。

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マイクロ流体核酸分析

従来のゲル分離を簡略化し、わずかな時間でデータの再現性を向上させることができます。LabChip™自動マイクロ流体キャピラリー電気泳動技術を利用した分離では、ゲノムサンプルを数十秒で分析できます。

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In Vivo Imaging Instruments

Whether you’re trying to understand biology pathways, monitor disease progression, or evaluate drug candidates earlier in drug development, our wide portfolio of preclinical imaging systems are designed to meet your research needs.

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High Content Screening Instruments
ハイコンテントスクリーニング装置

ハイコンテント解析(HCA)またはハイコンテントスクリーニング(HCS)は、ハイスループットの自動イメージングと解析を組み合わせ、シングルセルレベルで定量的なマルチパラメトリックデータを抽出します。

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cell-img
Cellular Imaging Software

Revvityは、より効果的かつ効率的に画像データを取得、可視化、解析、共有するための洗練された細胞イメージングおよび画像解析ソフトウェアを提供しています。

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immunoassays
イムノアッセイ

1950年代にイムノアッセイが導入されて以来、イムノアッセイは研究や創薬に不可欠な要素となってきました。

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In vitro assay

Leverage reliable in vitro assays to help better understand the interactions of the innate and adaptive immune response for your discovery and development of immunotherapies

We offer a range of assays for characterizing cytokine response, screening biologics, measuring signalling events, determining mechanism of action, and understanding the antibody-dependent cellular cytotoxicity (ADCC) of the biologic.

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Luminescence Assays

Luciferase assays allow for the study of transcriptional gene expression, virus life cycles, and cell viability.

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放射性物質の検出

放射性物質検出は、薬物経路の分析、研究室の環境保護、環境汚染の評価、食品の安全性のモニタリングなど、多くの科学的用途で研究者に使用されてきたゴールドスタンダードであり、現在もその地位を維持しています。

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Radionuclides

Radionuclides provide a highly specific and sensitive labeling option for proteins, cells, and tissues.

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Immune Cell Screening

Preclinical screening services using primary human immune cells to address biologically relevant questions for target identification and lead optimization

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immunoassays
イムノアッセイ

1950年代にイムノアッセイが導入されて以来、イムノアッセイは研究や創薬に不可欠な要素となってきました。

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microplate readers
マイクロプレートリーダー

Revvityのプレートリーダー製品群は、今日のラボの多様なアッセイ要件に対応する最新の検出技術を備えています。

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Featured resources

Infographic

Safety rules with Revvity biotherapeutic workflows

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Application note

Assessment of drug efficacy and toxicity by combining innovative technologies

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Application note

Development of pharmacokinetic (PK) assays for detecting biosimilars targeting TNF alpha using AlphaLISA

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Webinar

Antibody drug conjugates: A novel targeted approach to cancer therapy

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