Protein Aggregation

Understanding neurotoxic protein aggregates

Protein aggregates and resulting toxic inclusions are considered hallmarks of many neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and ALS. The investigation into proteionopathies that wreak havoc on the normal functioning of the brain is an active field within both basic and drug discovery research.

Revvity offers a range of reagents, consumables, instruments, and corresponding software to accelerate your neuroscience research with end-to-end high-throughput screening and high-content imaging solutions. We offer reliable high-throughput immunoassays employing HTRF® and AlphaLISA™ technology that are cost-effective alternatives to traditional ELISAs. These can be used to look at important protein aggregate markers such as tau, amyloid β, NFL, and TDP-43 on the VICTOR® Nivo™ or EnVision® multimode plate readers, as well as the Opera Phenix® Plus High Content Screening System with its accompanying Harmony® software and Columbus™ system, imaging dyes, and microplates for both 2D and 3D complex neurological disease modeling and drug discovery insights.