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      Revvity Impact Report

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  • Products
    • 研究・開発
      • ゲノム解析
        • IncRNA in Functional Studies
        • Nucleic Acid Isolation
        • NGSワークフロー
        • Microplate Readers
        • マイクロ流体核酸分析
        • CRISPR Technologies
        • RNA Interference
        • トランスフェクション試薬および補助試薬
        • Oligonucleotide Custom Synthesis
        • cDNAs and ORF Clones
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        • qPCR
        • ライブラリー調製キット
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        Revvity Impact Report

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      • タンパク質解析
        • Binding Assays
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        • Microplate Readers
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      • 細胞分析
        • Cell Isolation
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        • セルヘルスと細胞生存率
        • Cellular Imaging & Analysis
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        Revvity Impact Report

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      • 研究ソリューション
        • Immunoassays Solutions
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        • Physiological Model Solutions
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        Revvity Impact Report

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        Impact Report

      Revvity Impact Report

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    • 臨床・診断
      • リプロダクティブ・ヘルス
        • 出生前検査
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        • Newborn Sequencing Research
        • Pregnancy-Relevant Infections
        • Endocrine Reproductive
        • cell-free DNA解析
        • Neonatal Research
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        • PlGF Testing Research
        • 分子細胞遺伝学
      • 感染症
        • 結核マネジメント
        • EUROIMMUN Solutions
        • IDS Solutions
        • Nucleic Acid Isolation for Pathogen Detection
        • Cytomegalovirus
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        • Metagenomics
      • がん
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      • 自己免疫(powered by Euroimmun)
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      • 内分泌学
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      • 神経変性
        • Alzheimer's Disease
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        • Neurogranin
        • BACE1
      • ラピッド検査
    • Reagents
      • BioLegend
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      • Cellular Imaging Reagents
        Revvity Impact Report

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      • chemagic Nucleic Acid Purification Kits
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      • CRISPR Technologies
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      • GPCR Research Reagents
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      • Immunoassays
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      • In Vivo Imaging Reagents
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      • Liquid Scintillation Cocktails
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      • NGS Library Prep Kits
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      • pHSense Reagents
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      • qPCR
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      • Radiochemicals
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      • RNA Interference
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      • Primary and Secondary Antibodies
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    • プラットフォームと自動化
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        • chemagic Applications
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        • chemagic Kits
        • M-PVA Magnetic Beads
      • 自動液体分注
        • Flow Cytometry Cocktail Prep Automation
        • リキッドハンドリングワークステーション
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        • 液体分注機消耗品&アクセサリー
      • 統合ラボオートメーション
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        • ワークステーションモジュール
        • スケジューリング&コントロールソフトウェア
        • ロボット工学
      • マイクロ流体分析
        • Microfluidic Protein Characterization
        • Microfluidic Nucleic Acid Analysis
      • 検出システムソリューション
        • Plate Reader Accessories
        • マイクロプレートリーダー
        • 放射性物質の検出
        • 放射性化学物質
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        • 放射線測定用消耗品・アクセサリー
      • イメージング
        • Cellular Imaging & Analysis
        • In vivo イメージング
      • Cell Counting and Image Cytometry
      • サンプルのホモジナイゼーション
        • ホモジナイザー
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        • サンプルの遠心分離
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      • IVDプラットフォーム&オートメーション
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        • EUROIMMUN Instruments
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      • 消耗品&アクセサリー
        • Cassettes
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      • Instrument Service & Maintenance
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    • Signals ソフトウエア
      • All Products
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      • All Solutions
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    • Revvity Omics Services
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  • Services
    • Preclinicalサービス
      • Antibody Drug Conjugate Services
      • Complex Cell Model Screening Services
      • Base Editing Platform
        • Pin-point塩基編集プラットフォーム細胞株エンジニアリングサービス
        • Pin-point base editing platform pooled tiled screening services
      • 免疫細胞スクリーニング
      • Functional Genomic Screening Services
      • 細胞パネルスクリーニング
      • Cell Line Engineering
        • CHOSOURCE CLE Services
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    • Revvity Omics Services
      • Revvity Omics Clinical Services
        • Cytogenomics
        • Global Laboratory Network
        • Metabolic Testing
        • Newborn Screening Services
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        • Proactive Testing
        • Rare Disease Testing
        • Specialized and Customized Assays
        • Sponsored Testing Programs
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Revvity Omics Pharma Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • 臨床サービス
      • Revvity Omics Clinical Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Revvity Omics Pharma Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Cellular and Humoral Immunoassays
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Tuberculosis Testing Services
        • Oxford Diagnostic Laboratories Service Closures
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • Customization Services
      • Assays and Reagents
        • Assay Development
        • Compound profiling
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Microplate Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Custom Conjugation & Labeling
        • Custom Labeling
        • Small Molecule
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Radiosynthesis and Labeling
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • ライセンシング
      • Gene Delivery Licensing
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      • AAV Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Lentivirus Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • Instrument Service & Maintenance
      • AV Services
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • Equipment Service Plans
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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      • On-demand Equipment Service
        T-SPOT.TB testing services.

        Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

        Learn more

      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    • Customer Training
      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

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    • OEM ソリューション
      T-SPOT.TB testing services.

      Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

      Learn more

    T-SPOT.TB testing services.

    Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.

    Learn more

  • 会社
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  • Brands
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  • ホーム
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    • 分子細胞遺伝学
  • Preeclampsia Testing
    • Biochemical Prenatal Testing
    • Preeclampsia Testing
    • Vanadis NIPT System

Pre-eclampsia Testing

Preeclampsia is a pregnancy complication affecting between two and eight out of every 100 pregnant women.

The exact cause is unknown, but its risks are clear: left untreated, preeclampsia can cause growth-restriction or preterm birth of the child, and in some cases, lead to maternal and perinatal mortality. But with screening, the more severe forms of pre-eclampsia, early-onset and preterm preeclampsia, could be predicted and prevented.

Early screening and better care - solutions for effective pre-eclampsia management
 

When it comes to preeclampsia prevention, the earlier you identify women as having a high risk for developing the condition, the better the outcome for mother and child. Based on evidence from research studies, such as the ASPRE study, a combined screening program is recommended at 11–13 weeks' gestation to identify women at high risk of preeclampsia, when steps can still be taken to prevent its onset.

Later in the pregnancy 20 weeks onwards, angiogenic markers can be used to help identify women with increased risk for developing preeclampsia in the coming days. 
 

Revvity does not endorse or make recommendations with respect to research, medication, or treatments. All information presented is for informational purposes only and is not intended as medical advice. For country specific recommendations please consult your local health care professionals.

For in vitro diagnostic use. This product is only available where licensed in accordance with the law. Please contact your local representative for availability.

preeclampsia testing
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    infographic-trimesters-preeclampsia-v2

    1st trimester: Specific marker for pre-eclampsia - PIGF

    In pregnancies that develop preeclampsia, maternal serum placental growth factor (PlGF) levels decrease significantly in the first trimester. This makes it an important biomarker used to predict the onset of preeclampsia. Our high-sensitivity PlGF 1-2-3™ assay is optimized for first trimester screening of preeclampsia and is the only assay which was clinically validated by the ASPRE trial.

    The same blood sample can be used for both preeclampsia and aneuploidy screening using the same instrument and markers; no additional blood sample is required.

    Combined screening model

    Based on the evidence from research studies, international guidelines are recommending a combined screening program for preeclampsia at 11-13+6 weeks as the most effective way to identify women at high risk of pre-eclampsia in the early stages of pregnancy.

    The combined screening program is made up of four simple steps that require short training and minimal additional investment In equipment. Our Lifecycle™ software can generate a unique patient risk profile and report based on these combined screening markers.

    • Medical history
    • PlGF blood test
    • Blood pressure
    • Ultrasound (if available}

    2nd and 3rd trimester: PIGF as a single marker or sFlt-1/PIGF ratio

    Women with signs or symptoms of preeclampsia do not always develop preeclampsia. Angiogenic markers can be used to help identify women with increased risk for developing preeclampsia in the coming days.

    After 20 weeks of pregnancy PlGF and sFlt-1 are both predictive and diagnostic for preeclampsia. Determining serum PlGF concentration, used as a single marker, or sFlt-1 and PlGF, used as a ratio, improve the clinical management and decision making (risk stratification) with women showing signs and symptoms of preeclampsia.

    PlGF alone and sFlt-1/PlGF ratio have comparable performance for preeclampsia rule-in and rule-out, and both options are equally recommended for clinical use.  However, PLGF alone, with concentration-based cut-offs, could provide simpler and more affordable alternative to dual biomarker testing.

    Using PlGF has additional advantages. Studies have shown that PlGF is a good marker (decreased serum PlGF level) for identifying pregnancies with placental insufficiency including fetal growth restriction and/or stillbirth.

    User configurable laboratory data management

    Lifecycle™ software enables monitoring of preeclampsia status with PlGF concentration or the sFlt-1/PlGF ratio. The results can be linked to the patient case in Lifecycle™ software allowing the user to track samples and view all available results in one place. The assay cut-offs for preeclampsia management are user configurable and the software can be tailored to population.

    Explore our biochemical prenatal & preeclampsia testing applications

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    Biochemical Prenatal & Preeclampsia Testing Instruments

    Take advantage of the high analytical sensitivity of DELFIA® chemistry with your choice

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    Biochemical Prenatal & Preeclampsia Testing Kits

    Revvity offers a comprehensive range of prenatal and pre-eclampsia assays with high analytical sensitivity of the DELFIA® chemistry.

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    Risk Calculation Software

    We offer complete solutions to monitor both maternal and fetal health during pregnancy.

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    Pregnancy Complications

    We deliver complete screening solutions for a wide range of pregnancy complications – and more than 9 million prenatal risk assessments are done every year using those tests.

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    Featured resources

    Brochure

    PlGF 1-2-3™ brochure for pre-eclampsia

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    Brochure

    DELFIA® Xpress Pre-eclampsia management in 2T/3T

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    Webinar

    1st Trimester Pre-Eclampsia Screening – Is It Worth It?

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    Webinar

    Advancing preeclampsia care: from screening implementation to prevention strategies

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    Video

    Preeclampsia patient story Suzie

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    View all resources View all resources

    References:

    Daniel L. Rolnik et al. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia. DOI: 10.1056/NEJMoa1704559, New England J Med June 2017 

    Wright D et al. Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia. Am J Obstet Gynecol. 2017 Sep 6 

    Poon LC et al., ASPRE trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and 
    medical and obstetrical history. Am J Obstet Gynecol 2017 

    Kuklina EV, et al. Hypertensive Disorders and Severe Obstetric Morbidity in the United States. Obstet Gynecol 2009; 113:1299-306 

    COMPARE study: Performance of commercially available placental growth factor tests in women with suspected preterm pre-eclampsia, Ultrasound in Obstetric Gynecology​ 

    Herraiz et al Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1/PlGF Ratio in Singleton Pregnancies. Fetal Diagn Ther (2017) PROGNOSIS Hund et al. BMC Pregnancy and Childbirth 2014, 14:324 

    ISUOG Practice Guidelines: role of ultrasound in screening for and follow-up of pre-eclampsia, Ultrasound Obstet Gynecol 2018 DOI: 10.1002/uog.20105 

    Poon L, et al. The International Federation of Gynecology and Obstetrics (FIGO) Initiative on Pre-eclampsia: A Pragmatic Guide for First-Trimester Screening and Prevention. International Journal of Gynegology & Obstetrics. May 2019 

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