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細胞イメージング用マイクロプレート

ハイコンテントスクリーニング用に設計されていないマイクロプレートは、フォーカスのあっていない画像による不正確なデータになることがあります。その結果、データの確認や、サンプルの再スクリーニングなど、プロジェクトスケジュールの遅延、コストの増加などを生じます。

Revvityでは、これまでのハイコンテントスクリーニングの経験に基づき、ハイコンテントイメージングに最適なマイクロプレートを開発しました。PhenoPlateは、最高品質のデータを提供できるように設計しています、

2021年9月15日より、CellCarrier UltraプレートはPhenoPlatesに名称変更しました。

さらに、プレートリーダーのボトムリーディングシステムやハイコンテントイメージング用に設計されたViewPlate™マイクロプレートもあります。イメージングのみならず、蛍光、ルミネッセンス、吸光度などの細胞ベースの生化学アッセイアプリケーションや、組織培養処理された細胞培養にも使用することができます。

特徴

  • シクロオレフィンの高い光透過性​
  • ガラス底に匹敵する優れた平面性​
  • 薄いウェル底厚(188 μm)​
  • 水浸レンズや高倍率の対物レンズにも対応可能な低ウェル底設計​
  • 蒸発を低減する新デザインのフタ​
  • プレートを重ねた時もウェル底がキズがつかない底面デザイン​
  • 用途に合わせコーティングも可能
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研究用です。診断にはご使用いただけません。
 

細胞イメージング用マイクロプレート
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Application Note
Application Note
Alpha Terbium SureFire Ultra Multiplex: simultaneous dual phosphoprotein target analysis

Evaluating pharmaceutical compound efficacy and safety in regulating cell behavior can involve the study of multiple signal transduction pathways and measuring more than one cellular target can provide greater confidence of positive compound hits on the cellular target of interest. Protein phosphorylation has been identified as a useful readout of cellular activation or inhibition, and these pathways are commonly targeted for therapeutic modulation of disease. Numerous assay technologies are available to look at protein phosphorylation for drug development, including the AlphaLISA ™ SureFire ® Ultra which provides a highly sensitive, fully homogenous option for the analysis of signaling pathways. This application note details the implementation of multiplexing with the AlphaLISA SureFire Ultra Multiplex assay, which offers a homogenous and high throughput approach to multiplexing.

Technical Note
Technical Note
Automated high-content assay using GrowDex-embedded spheroids dispensed on JANUS G3 automated liquid handling workstation

When working with 3D cell models, high heterogeneity between samples can pose a challenge - either biological or technical. In this application note, we demonstrate how a JANUS G3 liquid handling workstation can be used to improve throughput as well as assay statics by automating the liquid handling steps of 384-well, hydrogel-based high-content toxicity assay.

Flyer
Flyer
Better microplates means better results

We know you are working hard to produce the next big breakthrough and the last thing you need to worry about is sub-par quality in something so commonly used, yet often overlooked, as a microplate.

FAQ
FAQ
Cell painting: your questions answered

With powerful potential for phenotypic drug discovery, cell painting is being rapidly adopted by leading scientists across the globe. However, implementing cell painting assays can present some challenges. To help you avoid some of the common pitfalls, we’ve collated answers from our experts to the top questions that we’ve been hearing from scientists and researchers. You will learn: How to choose the cell model What to look for in labelling reagents Key considerations for image acquisition Recommendations for image analysis Data analysis approaches

Flyer
Flyer
Comprehensive microplates overview

Application Note
Application Note
Evaluation of drug selectivity and efficacy using PROTACs in a 3D co-culture spheroid model

Read this brochure to get more information about the chemagic Prime Jr intrument for automated nucleic acid purification and assay setup and its application fields.

eBook
eBook
Guide to selecting a microplate

Your specific applications deserve the best microplates! For a researcher, the need to select the most suitable application-specific microplates is critical. Format, color, and surface properties are among the different features that can impact your assay performances and the quality of your results. Covering a vast array of application areas and over many years, Revvity has been committed to offering you high quality plates for the highest quality results. Download this guide and let us walk you through the process of choosing the correct microplate for your specific application.

Literature - Publication Review
Literature - Publication Review
hESC-derived cardiomyocyte screening platform identifies novel inhibitors of SARS-Cov-2 viral entry

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. Studies have shown that patients infected with SARS-CoV-2 with cardiovascular comorbidities are more susceptible to severe infection and thus the case fatality rate in these patients rises. To further understand the pathology of SARS-CoV-2 in cardiomyocytes, a team of researchers from the University of Cambridge in the UK, have developed a screening platform using human embryonic stem cell-derived cardiomyocytes (hESC-CMs).

Flyer
Flyer
Microplates for Cell Culture

Revvity’s CulturPlates and PhenoPlates are specifically designed to promote cell attachment and growth. These microplates are appropriate for not only cell culture, but also imaging or fluorescence and luminescence assays.

Application Note
Application Note
Multi-parametric assessment of EGF treatment effects on signaling pathways, growth and proliferation using AlphaLISA SureFire Ultra and cellular imaging

In this application note, we demonstrate an efficient cell-based workflow for the assessment of EGF treatment effects in a cellular model of human skin cancer. Treatment effects on several intracellular signaling pathways were examined using Revvity’s homogeneous, no-wash AlphaLISA ™ SureFire® Ultra assays. To determine concurrent time-dependent effects of different EGF concentrations on cellular health and proliferation, ATP concentrations were assessed with ATPlite ® 1step luminescence assay and cultures were fluorescently labeled, imaged and analyzed using the Operetta CLS™ high-content analysis system.

Application Note
Application Note
Multi-parametric high-throughput analysis of hepatotoxicity using a 3D primary liver cell culture model

3D cell cultures offer a more physiologically relevant option, but there are currently only a few high throughput screening (HTS) 3D systems that have high consistency and easily allow integration with downstream analysis methods. In this application note, we demonstrate the creation of an advanced 3D primary human hepatocyte (PHH) model using the RASTRUM platform that seamlessly integrates with Revvity’s HTS technologies.

Technical Note
Technical Note
PhenoPlate 384-well - Dedicated Design for High-Content Screening

This is a technical note for PhenoPlate 384-well microplates

Product Info
Product Info
PhenoPlate 384-well Product Information Sheet

Product Info
Product Info
PhenoPlate 96-well Product Information Sheet

This is a product information sheet for PhenoPlate 96-well imaging microplates.

Flyer
Flyer
PhenoPlates for High-Content Screening

Flyer describing PhenoPlates for High-Content Screening

Flyer
Flyer
PhenoPlates for High-Content Screening