M-PVA Magnetic Beads
Develop your own assay with robust family of chemagic™ M-PVA magnetic beads enhanced by a vast range of functionalities
Our M-PVA magnetic beads are small iron oxide particles encapsulated in a matrix of polyvinyl alcohol. Their functional group defines their binding affinity to either nucleic acids, proteins or biomolecules. These paramagnetic beads are designed to exhibit strong magnetic properties, allowing them to be manipulated using an external magnetic field. Thus, they are ideal for extraction of target molecules from a complex mixture. Applications of magnetic beads span various fields, including biology, chemistry, medicine, and materials science.
Outstanding properties
- Superparamagnetic, exhibit magnetic behavior only in the presence of an external magnetic field
- High magnetite content for fast magnetic separation, even from large sample volumes
- Polydisperse particles for a uniform magnetic separation
- Micrometer (µm) sized beads present a high active surface per volume and allow efficient adaptation to specific applications, available in two different size ranges (0.6-1.25 µm and 0.8-3 µm)
- Mechanical robustness allows different kinds of processing and facilitates automated use
- Chemical functionalization of the matrix with different modifications for high and specific binding capacity
- Hydrophilicity of the PVA surface, leading to low non-specific protein binding
- High thermal stability enabling easy sterilization by autoclaving*
* not applicable for all M-PVA Magnetic Beads.
Functionalization
Surface chemistry options have undoubtedly expanded the possibilities in numerous applications. However, the diversity of scientific research and industrial requirements often call for personalized solutions. That's where our expertise in custom bead conjugation comes into play.
- DNA/RNA binding with carboxylated magnetic beads
- Magnetic Streptavidin beads for biotinylated targets
- M-PVA Magnetic Oligo dT Beads for mRNA binding
- Protein binding with NHS activated magnetic beads
- Size selection bead solution for NGS reaction clean up (coming soon)
- IVT reaction clean up beads (coming soon)
Reveal what´s possible.
Are you facing a unique challenge that demands a custom ligand conjugation? Or perhaps your project necessitates a specific particle size that standard offerings cannot fulfil? Look no further - at Revvity, we empower you to tailor our M-PVA Magnetic Beads to precisely meet your distinct requirements. Our dedicated team of customization experts is committed to guiding you through every step of the process, from defining product specifications to seamless delivery completion.
Benefit from our vast resources in research and development, as well as our extensive manufacturing capabilities. Drawing on our rich history of supplying magnetic beads to renowned kit manufacturers, we guarantee custom magnetic bead technology that is ready to use with little or no need for further modification. Whether it's completing intricate conjugations or conducting rigorous quality control tests before the beads leave our factory, we are fully equipped to cater to your unique needs and ensure exceptional results.
When it comes to custom bead conjugation solutions, Revvity is your ideal collaborator enabling you to achieve ground-breaking advancements in your research and applications. Collaborate with us and experience the difference of tailor-made magnetic beads that redefine possibilities in your field.
Start an OEM partnership with us now!
For research use only. Not for use in diagnostic procedures.
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Size selection beads
This method of size directed nucleic acid extraction is commonly known as SPRI (Solid Phase Reversible Immobilization). Revvity’s size selection beads are designed for rapid manual and automated clean up and size selection of DNA and RNA fragments from a variety of reaction mixtures, used in NGS library preparations.
Clean-up of RNA and DNA with typical recovery yields for DNA ≥ 80 %, and for RNA between 70–100%.
Size Selection: The typical sample amount of double stranded DNA fragments is 5 ng to 1 µg. By using the tunable size selection method DNA fragment libraries with a size range of 150 bp to 800 bp can be produced. All components can be kept and processed completely at room temperature.
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IVT reaction clean-up kit
The IVT reaction clean-up kit enables fast and simple purification and concentration of up to 500 µg of RNA from in vitro transcription (IVT) and other enzymatic reactions.
- Ideal for purification of synthesized RNA following high-yield in vitro transcription reactions
- Optimized for the clean-up of RNA after enzymatic treatments including DNase I, Proteinase K, labeling and capping
- Efficiently purify RNA ≥ 25 nt (a simple modification enables purification of RNA ≥ 15 nt)
- Elute in ≥ 50 µl for concentrated RNA with 70-100% RNA recovery
- Purified RNA is ready for use in a wide variety of downstream applications, including microinjection and transfection.
- All components can be kept and processed completely at room temperature.
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M-PVA Magnetic Beads functionalized with streptavidin are commonly used for the isolation of biotinylated target molecules, such as oligos, mRNA and proteins. Incorporating the outstanding properties of M-PVA Magnetic Beads, the streptavidin modified ones show a higher biotin binding capacity compared to competitors and are produced with stringent quality controls, ensuring good lot-to-lot conformity. chemagic M-PVA SAV Magnetic Beads can be used in diverse downstream applications including nucleic acid enrichment or depletion for NGS, immunoprecipitation, protein purification, enrichment of sample/cells/organelles, and more. M-PVA Magnetic Beads functionalized with streptavidin are commonly used for the isolation and handling of nucleic acids and biotinylated ligands and targets, including antigens and antibodies. Immobilized Streptavidin on the surface of the beads empower binding and immobilization of biotinylated target molecules, such as oligos, ssDNAs, proteins. Binding capacity: > 3000 pmol free biotin/mg M-PVA SAV Magnetic Beads > 800 pmol ssOligo/mg M-PVA SAV Magnetic Beads > 30 pmol biotinylated protein/mg M-PVA SAV Magnetic Beads
M-PVA E02 Magnetic Beads with an epoxidated PVA matrix are designed for specific ligand coupling applications. The incorporation of epoxide functional groups onto the PVA surface enables the covalent attachment of ligands containing amino- or thiol-groups. The high magnetite content gives the beads superparamagnetic properties, enabling their rapid separation in the presence of a magnetic field, suitable for automated magnetic separation processes. Our dedication to innovation does not stop here. We understand that every researcher's needs are unique. That is why we offer an array of bead types to suit diverse applications. Plus, all our bead variants are available as OEM products, allowing you to customize your experience with individual packing sizes at competitive prices. Contact us today to discover a new dimension of possibilities in your research.
Carboxylated M-PVA Magnetic Beads for easy coupling of diverse molecules. Carboxylated M-PVA Magnetic Beads contain carboxyl (COOH) functional groups on the surface, which allows for easy and controlled coupling of various molecules, including proteins, nucleic acids, or other amino ligands. M-PVA Magnetic Beads are made from a matrix of polyvinyl alcohol (PVA). This material provides a stable and inert structure for the beads, allowing for further functionalization and use in various applications. The high content of magnetite in our carboxylated beads gives them superparamagnetic properties. This means that the beads become magnetized when exposed to a magnetic field but lose their magnetization once the field is removed, making them compatible with the automated magnetic separation platforms such as chemagic 360 or chemagic Prime instrument for rapid separation processes, even in complex environments with high volume.