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Biochemical Prenatal Testing

Tailored solutions to support your screening needs

When it comes to risk assessment and diagnosis of prenatal aneuploidy, early detection is essential. Clinically validated assays, combined with one of three scalable technology platforms and our Lifecycle ™ software for risk calculation, laboratories and clinics can achieve optimized screening performance while maximizing operational efficiency.

Whatever your preferred biochemical screening model, our assays offer tailored solutions for screening needs in the first and second trimester.

Wide range of solutions for 1st and 2nd trimester:

  • 1T Quad – accurate results even without NT (Nuchal Translucency) 
  • 1T DBS – Dried Blood Spot assays with same clinical performance as serum assays 
  • 2T Double 
  • 2T Triple 
  • 2T Quad 
  • 2T AFP – for neural tube defect screening


Revvity does not endorse or make recommendations with respect to research, medication, or treatments. All information presented is for informational purposes only and is not intended as medical advice. For country specific recommendations please consult your local health care professionals. 

Products may not be licensed in accordance with the laws in all countries, such as the United States and Canada. Please check with your local representative for availability. 

Biochemical Prenatal Testing

1st trimester

In the first trimester, our four CE-marked assays – PAPP-A, free hCGß, PlGF and AFP – provide effective screening for aneuploidy. Additionally, the PlGF marker can be used for preeclampsia screening from a single sample. Our dried blood spot assays provide the same clinical performance as first trimester serum assays and supports easier access to screening in regions where storage of serum samples can be a challenge.

In the first trimester, our four CE-marked assays – PAPP-A, free hCGß, PlGF and AFP – provide effective screening for aneuploidy. Additionally, the PlGF marker can be used for preeclampsia screening from a single sample. Our dried blood spot assays provide the same clinical performance as first trimester serum assays and supports easier access to screening in regions where storage of serum samples can be a challenge.

2nd trimester

In the second trimester, our assay solutions enable you to run the cost-effective Double test or enhance your screening performance using the Triple test or 2T QUAD test. The human alpha-fetoprotein (AFP) marker offered as part of the first trimester Down syndrome screening panel can also be used for neural tube defect screening in the second trimester.

In the second trimester, our assay solutions enable you to run the cost-effective Double test or enhance your screening performance using the Triple test or 2T QUAD test. The human alpha-fetoprotein (AFP) marker offered as part of the first trimester Down syndrome screening panel can also be used for neural tube defect screening in the second trimester.

Risk assessment

The Lifecycle™ software provides a complete data management solution for your laboratory, but at its heart is our Risk Calculation Engine. It has been designed to perform multiple complex algorithms and manage a variety of screening models. The software is also user-configurable, meaning users can enter their own parameters based on MoM values to optimize performance for the local population.

The Lifecycle™ software provides a complete data management solution for your laboratory, but at its heart is our Risk Calculation Engine. It has been designed to perform multiple complex algorithms and manage a variety of screening models. The software is also user-configurable, meaning users can enter their own parameters based on MoM values to optimize performance for the local population.