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  • ホーム
  • Products
  • 研究・開発
  • 研究ソリューション
    • ゲノム解析
    • タンパク質解析
    • 細胞分析
    • 研究ソリューション
  • 機能ゲノミクススクリーニングソリューション
    • Immunoassays Solutions
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  • Arrayed Screening
    • Arrayed Screening
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Arrayed Screening

Arrayed screening offers a more targeted and detailed analysis of gene function. In this method, each gene perturbation is introduced into a separate well of a multi-well plate, enabling a clear correlation between the observed phenotype and the underlying genotype.

Arrayed screens are particularly advantageous for researchers interested in capturing detailed information on cellular responses to individual gene perturbations, why it is often used for confirmatory or validation screens. The primary read-out for arrayed screening is often imaging, which can be complemented with additional detection methods or sequencing techniques, facilitating a multi-parametric analysis. This approach proves especially useful for studying complex cell models, including primary cells and 3D cell cultures, where a higher level of experimental control is required.

In summary, arrayed screening provides researchers with a more comprehensive understanding of gene function by allowing the analysis of individual perturbations in a controlled environment. By leveraging imaging and other advanced analytical tools, scientists can explore the intricate relationship between genotype and phenotype, paving the way for enhanced drug discovery and precision medicine.

Advantages:

  • Multi-parametric read-outs
  • Suitable for more complex cell models 
  • More choices in reagent formats, including non-viral transfection and cherry-picking options 
  • Clear phenotype to genotype correlation 
  • Improved editing efficiency by targeting the same gene with several gRNAs in one well

Read-out methods:

  • Fluorescence or luminescence detection to analyse Cell Viability and Proliferation
  • Imaging - Cell Morphology, Biomarker Expression and Localization 
  • Live Cell Imaging – Differentiation, Migration
  • Proteomic and Metabolomic Profiling


For research use only. Not for use in diagnostic procedures.

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arrayed screening

Gene editing and modulation reagents

Selecting the appropriate format of reagents is the first critical step before starting a screen. We offer a variety of formats so that regardless of the scientific question, you may find one tosupport your experimental needs.

Learn more

Selecting the appropriate format of reagents is the first critical step before starting a screen. We offer a variety of formats so that regardless of the scientific question, you may find one tosupport your experimental needs.

Learn more

Sample prep and automation

These types of assays are often labor intensive and require many steps for re-suspending the CRISPR reagents, cell transfer, and treatment addition or staining. To accelerate your assay, we offer a full range of liquid handling, integrated laboratory automation, and cell counters that together with our specially designed microplates, improve your workflow and provide consistent and quality results.

Learn more

These types of assays are often labor intensive and require many steps for re-suspending the CRISPR reagents, cell transfer, and treatment addition or staining. To accelerate your assay, we offer a full range of liquid handling, integrated laboratory automation, and cell counters that together with our specially designed microplates, improve your workflow and provide consistent and quality results.

Learn more

Detection

Once it's time to acquire an image, options for read-outs can range from simple phenotypic or viability assays to multiparametric high-content analysis. Our line of sensitive yet powerful microplate readers, live cell imagers, and high-content analysis systems, plus innovative reagents enable you to accelerate your workflow and reduce costs.

Learn more

Once it's time to acquire an image, options for read-outs can range from simple phenotypic or viability assays to multiparametric high-content analysis. Our line of sensitive yet powerful microplate readers, live cell imagers, and high-content analysis systems, plus innovative reagents enable you to accelerate your workflow and reduce costs.

Learn more

Analysis

Once your gene-editing experiment is complete, you’re faced with readouts and large amounts of data that need to be analyzed. Our next generation informatics solutions help you to contextually analyze all that data, so you have more physiologically relevant results to make more informed decisions.

Learn more

Once your gene-editing experiment is complete, you’re faced with readouts and large amounts of data that need to be analyzed. Our next generation informatics solutions help you to contextually analyze all that data, so you have more physiologically relevant results to make more informed decisions.

Learn more

Services

To alleviate bandwidth and expertise gaps, Revvity’s preclinical services team can deliver functional genomic screening projects, including CRISPR knockout, CRISPR activation, CRISPR inhibition, Pin-Point™ Base Editing platform, and RNAi screening. Our services are designed to enhance decision-making and help to increase the likelihood of clinical trial success by delivering comprehensive datasets to guide your strategy.

Learn more

To alleviate bandwidth and expertise gaps, Revvity’s preclinical services team can deliver functional genomic screening projects, including CRISPR knockout, CRISPR activation, CRISPR inhibition, Pin-Point™ Base Editing platform, and RNAi screening. Our services are designed to enhance decision-making and help to increase the likelihood of clinical trial success by delivering comprehensive datasets to guide your strategy.

Learn more

Featured resources

Brochure

CRISPR workflow solutions brochure

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Flyer

Arrayed CRISPR screening solutions flyer

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